3-beta-HSD

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hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Identifiers
Symbol	HSD3B1
Alt. Symbols	HSDB3, HSD3B
Entrez	3283
HUGO	5217
OMIM	109715
RefSeq	NM_000862
UniProt	P14060
Other data
EC number	1.1.1.145
Locus	Chr. 1 p13-p11

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Identifiers
Symbol	HSD3B2
Entrez	3284
HUGO	5218
OMIM	201810
RefSeq	NM_000198
UniProt	P26439
Other data
EC number	1.1.1.145
Locus	Chr. 1 p13.1

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Identifiers
Symbol	HSD3B7
Entrez	80270
HUGO	18324
OMIM	607764
RefSeq	NM_025193
UniProt	Q9H2F3
Other data
Locus	Chr. 16 p11.2-12

3-beta-HSD (or 3-beta-hydroxysteroid dehydrogenase-isomerase) is an enzyme which catalyses the synthesis of progesterone from pregnenolone, 17-hydroxyprogesterone from 17-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone in the adrenal gland. It is the only enzyme in the adrenal steroidogenic pathway that is not a member of the Cytochrome P450 family.

1 Pathway
2 Clinical significance
3 References
4 External links

[edit] Pathway

Corticosteroid biosynthetic pathway in rat

[edit] Clinical significance

It is associated with congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.

[edit] References

[edit] External links

IUBMB entry for 1.1.1.145

KEGG entry for 1.1.1.145

BRENDA entry for 1.1.1.145

NiceZyme view of 1.1.1.145

EC2PDB: PDB structures for 1.1.1.145

PRIAM entry for 1.1.1.145

PUMA2 entry for 1.1.1.145

IntEnz: Integrated Enzyme entry for 1.1.1.145

MetaCyc entry for 1.1.1.145

Atomic-resolution structures of enzymes belonging to this class

This EC 1.1.1 enzyme-related article is a stub. You can help Wikipedia by expanding it.

This oxidoreductase article is a stub. You can help Wikipedia by expanding it.

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1 NAD/NADP acceptor	Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase

1.1.2 cytochrome acceptor	Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553)

1.1.3 oxygen acceptor	Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase

1.1.4 disulfide as acceptor	Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5 quinone/similar acceptor	Quinoprotein glucose dehydrogenase

1.1.99 other acceptors	Choline dehydrogenase