PDZ domain

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Molecular structure of the PDZ domain included in the human GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) protein
Identifiers
Symbol	PDZ
Pfam	PF00595
InterPro	IPR001478
PROSITE	PDOC50106
SCOP	1lcy
Available PDB structures: 1l1jB:248-262 1lcyA:388-442 1fc7A:151-232 1fc9A:151-232 1fcfA:151-232 1fc6A:151-232 1ueqA:426-492 1ujvA:639-680 1i92A:14-91 1g9oA:14-91 1q3oA:663-754 1q3pA:663-754 1uepA:778-859 1wfvA:1147-1226 1uewA:920-1007 2cs5A:517-602 1qavA:81-161 2pdzA:81-161 1z86A:81-161 1z87A:81-161 1pdr :466-544 1tq3A:313-391 1be9A:313-391 1bfeA:313-391 1tp5A:313-391 1tp3A:313-391 1um7A:386-464 1iu2A:65-149 1iu0A:65-149 1kefA:65-149 1zokA:224-308 1qlcA:160-244 2bygA:193-277 2fe5A:226-310 1wi2A:47-125 1whaA:871-947 1x5qA:728-812 1t2mA:993-1073 1um1A:974-1056 1wf8A:504-589 1gm1A:1357-1439 1oziA:1357-1439 1vj6A:1357-1439 1d5gA:1368-1450 3pdzA:1368-1450 1q7xA:1368-1450 1ujuA:1100-1189 1wi4A:22-94 1l6oA:254-339 1mc7A:251-336 1n7tA:1323-1407 1mfgA:1323-1407 1mflA:1323-1407 1uezA:140-219 1uf1A:279-357 1x5nA:211-289 1ihjA:17-103 1uhpA:249-336 1uitA:1240-1316 1x6dA:412-495 2csjA:10-94 1m5zA:988-1067 2cssA:605-688 1zubA:619-702 1wfgA:668-753 1ufxA:816-887 1qauA:17-96 1b8qA:17-96 1u38A:656-740 1u37A:656-740 1u3bA:656-740 1x45A:656-740 1p1dA:471-557 1p1eA:471-557 1x5rA:456-542 1v62A:248-329 1n7fA:672-751 1n7eA:672-751 1wf7A:5-82 1rgwA:4-81 1vb7A:3-81 1i16 :533-616 1v6bA:752-838 2f5yB:300-373 1whdA:18-92 1yboA:114-191 1v1tB:114-191 1obzB:114-191 1n99A:114-191 1wh1A:419-501 1va8A:256-333 1kwaA:490-568 1nf3D:157-247 1rzxA:160-250 1obyB:198-270 1obxA:198-270 1nteA:198-270 1r6jA:198-270 1u39A:747-820 1y7nA:747-820

The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, and animals^[1]. PDZ is an acronym combining the first letters of three proteins — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zonula occludens-1 protein (zo-1) — which were first discovered to share the domain. PDZ domains are also referred to as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains. These domains help anchor transmembrane proteins to the cytoskeleton and hold together signaling complexes^[2].

There are roughly 260 human PDZ domains, though since several PDZ domain containing proteins hold several domains, the actual number of PDZ proteins is closer to 180. Listed below are some of the better studied members of this family.

Erbin
Htra1
Htra2
Htra3
PSD-95
SAP97
PTP-BL ^[3]

1 Human proteins containing this domain
2 References
3 Further reading
4 External links

[edit] Human proteins containing this domain

AAG12; AHNAK; AHNAK2; AIP1; APBA1; APBA2; APBA3; ARHGAP21; ARHGAP23; ARHGEF11; ARHGEF12; C14orf112; C16orf65; CASK; CNKSR2; CNKSR3; DFNB31; DLG1; DLG2; DLG3; DLG4; DLG5; DVL1; DVL1L1; DVL2; DVL3; ERBB2IP; FRMPD1; FRMPD2; FRMPD2L1; FRMPD3; FRMPD4; GIPC1; GIPC2; GIPC3; GOPC; GRASP; GRIP1; GRIP2; HTRA1; HTRA2; HTRA3; HTRA4; IL16; INADL; KIAA1849; LDB3; LIMK1; LIMK2; LIN7A; LIN7B; LIN7C; LMO7; LNX1; LNX2; LOC392742; LOC392862; LRRC7; MAGI1; MAGI2; MAGI3; MAGIX; MAST1; MAST2; MAST3; MAST4; MLLT4; MPDZ; MPP1; MPP2; MPP3; MPP4; MPP5; MPP6; MPP7; MYO18A; NOS1; PARD3; PARD3B; PARD6A; PARD6B; PARD6G; PDLIM1; PDLIM2; PDLIM3; PDLIM4; PDLIM5; PDLIM7; PDZD11; PDZD2; PDZD3; PDZD4; PDZD5A; PDZD7; PDZD8; PDZK1; PDZRN3; PDZRN4; PICK1; PPP1R9A; PPP1R9B; PREX1; PRX; PSCDBP; PTPN13; PTPN3; PTPN4; RAPGEF2; RAPGEF6; RGS12; RGS3; RHPN1; RIMS1; RIMS2; SCRIB; SDCBP; SDCBP2; SHANK1; SHANK2; SHANK3; SHROOM2; SHROOM3; SHROOM4; SIPA1; SIPA1L1; SIPA1L2; SIPA1L3; SLC9A3R1; SLC9A3R2; SNTA1; SNTB1; SNTB2; SNTG1; SNTG2; SNX27; SPAL2; STXBP4; SYNJ2BP; SYNPO2; SYNPO2L; TAX1BP3; TIAM1; TIAM2; TJP1; TJP2; TJP3; USH1C; WHRN;

[edit] References

^ Ponting C (1997). "Evidence for PDZ domains in bacteria, yeast, and plants.". Protein Sci 6 (2): 464–8. PMID 9041651.
^ Ranganathan R, Ross E (1997). "PDZ domain proteins: scaffolds for signaling complexes.". Curr Biol 7 (12): R770–3. doi:10.1016/S0960-9822(06)00401-5. PMID 9382826.
^ Jemth, P., Gianni, S. (2007). "PDZ domains: folding and binding". Biochemistry 40 (30): 8701–8708. doi:10.1021/bi7008618. PMID 17620015.

[edit] Further reading

[1]. PDZ domains: targeting signalling molecules to sub-membranous sites. Ponting CP, Phillips C, Davies KE, Blake DJ Bioessays 1997;19:469-479. PubMed
[2]. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R; Cell. 1996;85:1067-1076. PubMed