PARD6B

From Wikipedia, the free encyclopedia

Par-6 partitioning defective 6 homolog beta (C. elegans)

PDB rendering based on 1nf3.

Available structures: 1nf3

Identifiers

Symbol(s)

PARD6B; PAR6B

External IDs

OMIM: 608975 MGI: 2135605 HomoloGene: 23302

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • plasma membrane • tight junction • cell cortex • apical part of cell
Biological Process:	• intercellular junction assembly • cell cycle • establishment and/or maintenance of cell polarity • axonogenesis • regulation of cell migration • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032521 (mRNA)
NP_115910 (protein)

NM_021409 (mRNA)
NP_067384 (protein)

Location

Chr 20: 48.78 - 48.8 Mb

Chr 2: 167.77 - 167.79 Mb

Pubmed search

[1]

[2]

Par-6 partitioning defective 6 homolog beta (C. elegans), also known as PARD6B, is a human gene.^[1]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans).

[edit] Further reading

Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.
Noda Y, Takeya R, Ohno S, et al. (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.". Genes Cells 6 (2): 107–19. PMID 11260256.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.". Gene 294 (1-2): 99–107. PMID 12234671.
Kohjima M, Noda Y, Takeya R, et al. (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.". Biochem. Biophys. Res. Commun. 299 (4): 641–6. PMID 12459187.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177.
Yamanaka T, Horikoshi Y, Sugiyama Y, et al. (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.". Curr. Biol. 13 (9): 734–43. PMID 12725730.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Labhart P, Karmakar S, Salicru EM, et al. (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator.". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. doi:10.1073/pnas.0409578102. PMID 15677324.