GOPC

From Wikipedia, the free encyclopedia

Golgi associated PDZ and coiled-coil motif containing

PDB rendering based on 2dc2.

Available structures: 2dc2

Identifiers

Symbol(s)

GOPC; FIG; CAL; GOPC1; PIST; dJ94G16.2

External IDs

OMIM: 606845 MGI: 2149946 HomoloGene: 10695

Gene ontology
Molecular Function:	• small GTPase regulator activity • transporter activity • cystic fibrosis transmembrane conductance regulator binding • syntaxin-6 binding
Cellular Component:	• cytoplasm • Golgi apparatus • plasma membrane • synaptosome • trans-Golgi network transport vesicle
Biological Process:	• ER to Golgi vesicle-mediated transport • Golgi to plasma membrane transport • autophagy • protein transport • cytoplasmic sequestering of CFTR protein • apical protein localization • protein homooligomerization

Orthologs

Human

Mouse

Refseq

NM_001017408 (mRNA)
NP_001017408 (protein)

NM_053187 (mRNA)
NP_444417 (protein)

Location

Chr 6: 117.99 - 118.03 Mb

Chr 10: 52.03 - 52.07 Mb

Pubmed search

[1]

[2]

Golgi associated PDZ and coiled-coil motif containing, also known as GOPC, is a human gene.^[1]

PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing.

[edit] Further reading

Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.". EMBO J. 17 (23): 6879–87. doi:10.1093/emboj/17.23.6879. PMID 9843494.
Neudauer CL, Joberty G, Macara IG (2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
Charest A, Lane K, McMahon K, Housman DE (2001). "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.". J. Biol. Chem. 276 (31): 29456–65. doi:10.1074/jbc.M104137200. PMID 11384996.
Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.
Cheng J, Moyer BD, Milewski M, et al. (2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression.". J. Biol. Chem. 277 (5): 3520–9. doi:10.1074/jbc.M110177200. PMID 11707463.
Yao R, Ito C, Natsume Y, et al. (2002). "Lack of acrosome formation in mice lacking a Golgi protein, GOPC.". Proc. Natl. Acad. Sci. U.S.A. 99 (17): 11211–6. doi:10.1073/pnas.162027899. PMID 12149515.
Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice.". Neuron 35 (5): 921–33. PMID 12372286.
Gentzsch M, Cui L, Mengos A, et al. (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Charest A, Kheifets V, Park J, et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. doi:10.1073/pnas.242741799. PMID 12538861.
Charest A, Lane K, McMahon K, et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).". Genes Chromosomes Cancer 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006.
Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST.". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
Cheng J, Wang H, Guggino WB (2004). "Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL.". J. Biol. Chem. 279 (3): 1892–8. doi:10.1074/jbc.M308640200. PMID 14570915.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
He J, Bellini M, Xu J, et al. (2005). "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.". J. Biol. Chem. 279 (48): 50190–6. doi:10.1074/jbc.M404876200. PMID 15358775.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Cheng J, Wang H, Guggino WB (2005). "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.". J. Biol. Chem. 280 (5): 3731–9. doi:10.1074/jbc.M410026200. PMID 15546864.
Hicks SW, Machamer CE (2005). "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST.". J. Biol. Chem. 280 (32): 28944–51. doi:10.1074/jbc.M504937200. PMID 15951434.