APBA3

From Wikipedia, the free encyclopedia

Amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)

Identifiers

APBA3; MGC:15815; X11L2; mint3

External IDs

OMIM: 604262 MGI: 1888527 HomoloGene: 3591

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane
Biological Process:	• intracellular signaling cascade • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004886 (mRNA)
NP_004877 (protein)

NM_018758 (mRNA)
NP_061228 (protein)

Location

Chr 19: 3.7 - 3.71 Mb

Chr 10: 80.67 - 80.68 Mb

Pubmed search

[1]

[2]

Amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2), also known as APBA3, is a human gene.^[1]

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.^[1]

[edit] References

^ ^a ^b Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2).

[edit] Further reading

Kuriyan J, Cowburn D (1997). "Modular peptide recognition domains in eukaryotic signaling.". Annual review of biophysics and biomolecular structure 26: 259-88. doi:10.1146/annurev.biophys.26.1.259. PMID 9241420.
Morishima-Kawashima M, Ihara Y (2002). "[Recent advances in Alzheimer's disease]". Seikagaku 73 (11): 1297-307. PMID 11831025.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Okamoto M, Südhof TC (1999). "Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2.". Eur. J. Cell Biol. 77 (3): 161-5. PMID 9860131.
Tanahashi H, Tabira T (1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein.". Biochem. Biophys. Res. Commun. 255 (3): 663-7. doi:10.1006/bbrc.1999.0265. PMID 10049767.
Tanahashi H, Tabira T (1999). "Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein.". Neuroreport 10 (12): 2575-8. PMID 10574372.
Okamoto M, Nakajima Y, Matsuyama T, Sugita M (2001). "Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane.". Neuroscience 104 (3): 653-65. PMID 11440799.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV.". J. Biol. Chem. 279 (19): 20461-70. doi:10.1074/jbc.M400264200. PMID 14990567.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Malmberg EK, Andersson CX, Gentzsch M, et al. (2005). "Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3.". J. Cell. Sci. 117 (Pt 23): 5535-41. doi:10.1242/jcs.01472. PMID 15494376.