Pargyline

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Pargyline
Systematic (IUPAC) name
N-Benzyl-N-methyl-prop-2-yn-1-amine
Identifiers
CAS number	555-57-7
ATC code	C02KC01 C02 LL01
PubChem	4688
Chemical data
Formula	C₁₁H₁₃N
Mol. mass	195.69 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Pargyline is a monoamine oxidase B (MAO-B) inhibitor. It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis.^[1]

[edit] References

^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006

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Psychoanaleptics: antidepressants (N06A)

MAOIs

Iproclozide • Iproniazid • Isocarboxazid • Minaprine • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine
RIMAs: Befloxatone • Brofaromine • Cimoxatone • Beta-carbolines (Harmaline) • Moclobemide

RIs

S RI	SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Femoxetine, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine) • TCAs/Tetras (Clomipramine, Nefazodone, Trazodone)

N RI / A RI	Atomoxetine • Maprotiline • Nisoxetine • Reboxetine • Talopram • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dosulepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Protriptyline, Trimipramine, Maprotiline)

D RI	Medifoxamine • Phenmetrazine • Vanoxerine • TCAs (Amineptine)

SN RI	Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine

ND RI	Bupropion • Nomifensine

SND RI	Brasofensine • Diclofensine • Tesofensine