SCN7A

From Wikipedia, the free encyclopedia

Sodium channel, voltage-gated, type VII, alpha

Identifiers

External IDs

OMIM: 182392 MGI: 102965 HomoloGene: 55706

Gene ontology
Molecular Function:	• voltage-gated sodium channel activity • sodium ion binding
Cellular Component:	• voltage-gated sodium channel complex • membrane fraction • membrane
Biological Process:	• ion transport • sodium ion transport • muscle contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002976 (mRNA)
NP_002967 (protein)

NM_009135 (mRNA)
NP_033161 (protein)

Location

Chr 2: 166.97 - 167.05 Mb

Chr 2: 66.47 - 66.59 Mb

Pubmed search

[1]

[2]

Sodium channel, voltage-gated, type VII, alpha, also known as SCN7A, is a human gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Sodium channel

[edit] References

^ Entrez Gene: SCN7A sodium channel, voltage-gated, type VII, alpha.

[edit] Further reading

Plummer NW, Meisler MH (1999). "Evolution and diversity of mammalian sodium channel genes.". Genomics 57 (2): 323-31. doi:10.1006/geno.1998.5735. PMID 10198179.
Meyers KJ, Mosley TH, Fox E, et al. (2007). "Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks.". Hypertension 49 (5): 992-9. doi:10.1161/HYPERTENSIONAHA.106.081265. PMID 17339538.
Zhang KX, Zhu DL, He X, et al. (2004). "[Association of single nucleotide polymorphism in human SCN7A gene with essential hypertension in Chinese]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20 (6): 463-7. PMID 14669210.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Goldin AL, Barchi RL, Caldwell JH, et al. (2001). "Nomenclature of voltage-gated sodium channels.". Neuron 28 (2): 365-8. PMID 11144347.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
George AL, Knops JF, Han J, et al. (1994). "Assignment of a human voltage-dependent sodium channel alpha-subunit gene (SCN6A) to 2q21-q23.". Genomics 19 (2): 395-7. PMID 8188276.
Boyle MB, Heslip LA (1995). "Voltage-dependent Na+ channel mRNA expression in pregnant myometrium.". Recept. Channels 2 (3): 249-53. PMID 7874451.
Han JA, Lu CM, Brown GB, Rado TA (1991). "Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 335-9. PMID 1846440.
George AL, Knittle TJ, Tamkun MM (1992). "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.". Proc. Natl. Acad. Sci. U.S.A. 89 (11): 4893-7. PMID 1317577.

[edit] External links

MeSH SCN7A+protein,+human

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel