HCN1

From Wikipedia, the free encyclopedia

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1

PDB rendering based on 1q3e.

Available structures: 1q3e, 1q43, 1q5o

Identifiers

Symbol(s)

HCN1; BCNG-1; BCNG1; HAC-2

External IDs

OMIM: 602780 MGI: 1096392 HomoloGene: 32093

Gene ontology
Molecular Function:	• nucleotide binding • voltage-gated potassium channel activity • sodium channel activity • cAMP binding • potassium ion binding • sodium ion binding
Cellular Component:	• membrane • integral to membrane • axon
Biological Process:	• ion transport • potassium ion transport • sodium ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021072 (mRNA)
NP_066550 (protein)

NM_010408 (mRNA)
NP_034538 (protein)

Location

Chr 5: 45.3 - 45.73 Mb

Chr 13: 118.72 - 119.1 Mb

Pubmed search

[1]

[2]

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1, also known as HCN1, is a human gene.^[1]

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM]^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Cyclic nucleotide-gated ion channel

[edit] References

^ ^a ^b Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1.

[edit] Further reading

Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. PMID 9405696.
Santoro B, Liu DT, Yao H, et al. (1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.". Cell 93 (5): 717–29. PMID 9630217.
Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels.". Nature 393 (6685): 587–91. doi:10.1038/31255. PMID 9634236.
Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain.". Hum. Genet. 103 (6): 666–73. PMID 9921901.
Ulens C, Tytgat J (2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels.". J. Biol. Chem. 276 (9): 6069–72. doi:10.1074/jbc.C000738200. PMID 11133998.
Proenza C, Tran N, Angoli D, et al. (2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.". J. Biol. Chem. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.
Chaplan SR, Guo HQ, Lee DH, et al. (2003). "Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.". J. Neurosci. 23 (4): 1169–78. PMID 12598605.
Lesso H, Li RA (2003). "Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype.". J. Biol. Chem. 278 (25): 22290–7. doi:10.1074/jbc.M302466200. PMID 12668666.
Bender RA, Soleymani SV, Brewster AL, et al. (2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.". J. Neurosci. 23 (17): 6826–36. PMID 12890777.
Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

[edit] External links

MeSH HCN1+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel

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HCN1

From Wikipedia, the free encyclopedia

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[edit] Further reading

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