HCN4

From Wikipedia, the free encyclopedia

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4

PDB rendering based on 1q3e.

Available structures: 1q3e, 1q43, 1q5o

Identifiers

Symbol(s)

HCN4;

External IDs

OMIM: 605206 MGI: 1298209 HomoloGene: 3997

Gene ontology
Molecular Function:	• nucleotide binding • voltage-gated potassium channel activity • sodium channel activity • cAMP binding • potassium ion binding • sodium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• cation transport • potassium ion transport • sodium ion transport • muscle contraction • circulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005477 (mRNA)
NP_005468 (protein)

XM_287905 (mRNA)
XP_287905 (protein)

Location

Chr 15: 71.4 - 71.45 Mb

Chr 9: 58.62 - 58.66 Mb

Pubmed search

[1]

[2]

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4, also known as HCN4, is a human gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Cyclic nucleotide-gated ion channel

[edit] References

^ Entrez Gene: HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4.

[edit] Further reading

Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
Ludwig A, Zong X, Stieber J, et al. (1999). "Two pacemaker channels from human heart with profoundly different activation kinetics.". EMBO J. 18 (9): 2323–9. doi:10.1093/emboj/18.9.2323. PMID 10228147.
Seifert R, Scholten A, Gauss R, et al. (1999). "Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9391–6. PMID 10430953.
Qu J, Altomare C, Bucchi A, et al. (2003). "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.". Pflugers Arch. 444 (5): 597–601. doi:10.1007/s00424-002-0860-7. PMID 12194012.
Schulze-Bahr E, Neu A, Friederich P, et al. (2003). "Pacemaker channel dysfunction in a patient with sinus node disease.". J. Clin. Invest. 111 (10): 1537–45. PMID 12750403.
Stieber J, Thomer A, Much B, et al. (2003). "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.". J. Biol. Chem. 278 (36): 33672–80. doi:10.1074/jbc.M305318200. PMID 12813043.
Decher N, Bundis F, Vajna R, Steinmeyer K (2004). "KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.". Pflugers Arch. 446 (6): 633–40. doi:10.1007/s00424-003-1127-7. PMID 12856183.
Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
Ueda K, Nakamura K, Hayashi T, et al. (2004). "Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.". J. Biol. Chem. 279 (26): 27194–8. doi:10.1074/jbc.M311953200. PMID 15123648.
Michels G, Er F, Khan I, et al. (2005). "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.". Circulation 111 (4): 399–404. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126.
Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D (2006). "Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.". N. Engl. J. Med. 354 (2): 151–7. doi:10.1056/NEJMoa052475. PMID 16407510.
Elinder F, Männikkö R, Pandey S, Larsson HP (2006). "Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.". J. Physiol. (Lond.) 575 (Pt 2): 417–31. doi:10.1113/jphysiol.2006.110437. PMID 16777944.
Nof E, Luria D, Brass D, et al. (2007). "Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia.". Circulation 116 (5): 463–70. doi:10.1161/CIRCULATIONAHA.107.706887. PMID 17646576.

[edit] External links

MeSH HCN4+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel

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HCN4

From Wikipedia, the free encyclopedia

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[edit] Further reading

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