From Wikipedia, the free encyclopedia
Lipotropin is a hormone produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which undergoes cleavage to adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).
[edit] Beta-lipotropin
β-lipotropin is a 90 amino acid polypeptide that is the carboxy-terminal fragment of POMC.
It stimulates melanocytes to produce melanin, and can also be cleaved into smaller peptides. In humans, γ-lipotropin, α-MSH, β-MSH, γ-MSH, α-endorphin, β-endorphin, γ-endorphin, and met-enkephalin are all possible fragments of β-lipotropin.[1]
β-lipotropin also performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
[edit] Gamma-lipotropin
γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids.
[edit] External links
[edit] References
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Endocrine system: hormones/endocrine glands (Peptide hormones, Steroid hormones) |
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| Hypothalamic-pituitary |
Hypothalamus: TRH, CRH , GnRH, GHRH, somatostatin, dopamine - Posterior pituitary: vasopressin, oxytocin - Anterior pituitary: α ( FSH, LH, TSH), GH, prolactin, POMC ( ACTH, MSH, endorphins, lipotropin)
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| Adrenal axis |
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| Thyroid axis |
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| Gonadal axis |
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| Other end. glands |
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| Non-end. glands |
Placenta: hCG, HPL, estrogen, progesterone - Kidney: renin, EPO, calcitriol, prostaglandin - Heart atrium: ANP - Stomach: gastrin, ghrelin - Duodenum: CCK, GIP, secretin, motilin, VIP - Ileum: enteroglucagon - Adipose tissue: leptin, adiponectin, resistin - Thymus: Thymosin - Thymopoietin - Thymulin - Skeleton: Osteocalcin - Liver/other: Insulin-like growth factor ( IGF-1, IGF-2)
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| Target-derived |
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