Calcitonin gene-related peptide

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calcitonin-related polypeptide, beta
Identifiers
Symbol	CALCB
Alt. Symbols	CALC2
Entrez	797
HUGO	1438
OMIM	114160
RefSeq	NM_000728
UniProt	P10092
Other data
Locus	Chr. 11 p14.2-p12

Calcitonin gene related peptide (CGRP) is derived, with calcitonin, from the CT/CGRP gene located on chromosome 11. CGRP is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known.

CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonised by capsazepine.^[1] CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches.

[edit] External links

MeSH Calcitonin+Gene-Related+Peptide

[edit] References

^ Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt ED (1999-07-29). "Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.". Nature 400 (6743): 452—457. PMID 10440374.

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v • d • e Peptides: neuropeptides

Hypothalamic	Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin)

Gastrointestinal hormones	Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide

Other hormones	Vasopressin - Calcitonin -

Other	Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide