G-protein coupled receptor kinases
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G-Protein coupled receptor kinases (GRKs), regulate the activity of G-protein coupled receptors by phosphorylating their intracellular domains after their associated G-proteins have been released and activated.
The phosphorylated serines and threonine residues act as binding sites for Arrestin proteins which prevent the reassociation of the G-proteins with their receptors, thereby preventing reactivation of the signaling pathway.
[edit] Types
| Name | Notes | OMIM | Gene |
| G-protein coupled receptor kinase 1 | #1 is rhodopsin kinase | 180381 | GRK1 |
| G-protein coupled receptor kinase 2 (BARK1) | #2 is beta adrenergic receptor kinase-1 | 109635 | ADRBK1 |
| G-protein coupled receptor kinase 3 (BARK2) | beta adrenergic receptor kinase-2 | 109636 | ADRBK2 |
| G-protein coupled receptor kinase 4 | #4 has been associated with regulation of kidney tubule function | 137026 | GRK4 |
| G-protein coupled receptor kinase 5 | Transgenic mice lacking #5 have altered core body temperature | 600870 | GRK5 |
| G-protein coupled receptor kinase 6 | Transgenic mice lacking #6 have altered response to leukotriene B4 | 600869 | GRK6 |
[edit] External links
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