GRK6

From Wikipedia, the free encyclopedia

G protein-coupled receptor kinase 6

PDB rendering based on 2acx.

Available structures: 2acx

Identifiers

Symbol(s)

GRK6; FLJ32135; GPRK6

External IDs

OMIM: 600869 MGI: 1347078 HomoloGene: 37570

Gene ontology
Molecular Function:	• nucleotide binding • G-protein coupled receptor kinase activity • signal transducer activity • ATP binding • transferase activity
Cellular Component:	• membrane
Biological Process:	• protein amino acid phosphorylation • signal transduction • regulation of G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001004105 (mRNA)
NP_001004105 (protein)

NM_001038018 (mRNA)
NP_001033107 (protein)

Location

Chr 5: 176.79 - 176.8 Mb

Chr 13: 55.46 - 55.47 Mb

Pubmed search

[1]

[2]

G protein-coupled receptor kinase 6, also known as GRK6, is a human gene.^[1]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: GRK6 G protein-coupled receptor kinase 6.

[edit] Further reading

Bullrich F, Druck T, Kunapuli P, et al. (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.". Cytogenet. Cell Genet. 70 (3-4): 250-4. PMID 7789183.
Stoffel RH, Randall RR, Premont RT, et al. (1994). "Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.". J. Biol. Chem. 269 (45): 27791-4. PMID 7961702.
Loudon RP, Benovic JL (1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.". J. Biol. Chem. 269 (36): 22691-7. PMID 8077221.
Benovic JL, Gomez J (1993). "Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.". J. Biol. Chem. 268 (26): 19521-7. PMID 8366096.
Haribabu B, Snyderman R (1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family.". Proc. Natl. Acad. Sci. U.S.A. 90 (20): 9398-402. PMID 8415712.
Freedman NJ, Ament AS, Oppermann M, et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.". J. Biol. Chem. 272 (28): 17734-43. PMID 9211925.
Loudon RP, Benovic JL (1997). "Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6.". J. Biol. Chem. 272 (43): 27422-7. PMID 9341194.
Stoffel RH, Inglese J, Macrae AD, et al. (1998). "Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.". Biochemistry 37 (46): 16053-9. doi:10.1021/bi981432d. PMID 9819198.
Premont RT, Claing A, Vitale N, et al. (1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14082-7. PMID 9826657.
Milcent MD, Christophe T, Rabiet MJ, et al. (1999). "Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells.". Biochem. Biophys. Res. Commun. 259 (1): 224-9. doi:10.1006/bbrc.1999.0758. PMID 10334944.
Lazari MF, Liu X, Nakamura K, et al. (1999). "Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.". Mol. Endocrinol. 13 (6): 866-78. PMID 10379886.
Hall RA, Spurney RF, Premont RT, et al. (1999). "G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.". J. Biol. Chem. 274 (34): 24328-34. PMID 10446210.
Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (1999). "Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium.". J. Endocrinol. 162 (3): 401-8. PMID 10467231.
Premont RT, Macrae AD, Aparicio SA, et al. (1999). "The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.". J. Biol. Chem. 274 (41): 29381-9. PMID 10506199.
Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000). "Synucleins are a novel class of substrates for G protein-coupled receptor kinases.". J. Biol. Chem. 275 (34): 26515-22. doi:10.1074/jbc.M003542200. PMID 10852916.
Tiruppathi C, Yan W, Sandoval R, et al. (2000). "G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7440-5. PMID 10861009.
Zhou H, Yan F, Tai HH (2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases.". J. Pharmacol. Exp. Ther. 298 (3): 1243-51. PMID 11504827.
Blaukat A, Pizard A, Breit A, et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.". J. Biol. Chem. 276 (44): 40431-40. doi:10.1074/jbc.M107024200. PMID 11517230.
Willets JM, Challiss RA, Nahorski SR (2002). "Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells.". J. Biol. Chem. 277 (18): 15523-9. doi:10.1074/jbc.M111217200. PMID 11856737.
Grange-Midroit M, García-Sevilla JA, Ferrer-Alcón M, et al. (2002). "G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution.". Brain Res. Mol. Brain Res. 101 (1-2): 39-51. PMID 12007830.