MAP2K2

From Wikipedia, the free encyclopedia

Main article: Mitogen-activated protein kinase kinase

Mitogen-activated protein kinase kinase 2

PDB rendering based on 1s9i.

Available structures: 1s9i

Identifiers

Symbol(s)

MAP2K2; MAPKK2; MEK2; MKK2; PRKMK2

External IDs

OMIM: 601263 MGI: 1346867 HomoloGene: 48591

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• extracellular region
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030662 (mRNA)
NP_109587 (protein)

XM_987766 (mRNA)
XP_992860 (protein)

Location

Chr 19: 4.04 - 4.08 Mb

Chr 10: 80.51 - 80.53 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase kinase 2, also known as MAP2K2, is a human gene.

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.^[1]

[edit] References

^ Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2.

[edit] Further reading

Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. PMID 16454711.
Charest DL, Mordret G, Harder KW, et al. (1993). "Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.". Mol. Cell. Biol. 13 (8): 4679–90. PMID 7687743.
Dérijard B, Raingeaud J, Barrett T, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.". Science 267 (5198): 682–5. PMID 7839144.
Alessi DR, Saito Y, Campbell DG, et al. (1994). "Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.". EMBO J. 13 (7): 1610–9. PMID 8157000.
Zheng CF, Guan KL (1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.". J. Biol. Chem. 268 (32): 23933–9. PMID 8226933.
Zheng CF, Guan KL (1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.". J. Biol. Chem. 268 (15): 11435–9. PMID 8388392.
Wu J, Harrison JK, Dent P, et al. (1993). "Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.". Mol. Cell. Biol. 13 (8): 4539–48. PMID 8393135.
Moriguchi T, Gotoh Y, Nishida E (1996). "Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.". Eur. J. Biochem. 234 (1): 32–8. PMID 8529659.
Butch ER, Guan KL (1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.". J. Biol. Chem. 271 (8): 4230–5. PMID 8626767.
Papin C, Denouel A, Calothy G, Eychène A (1996). "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system.". Oncogene 12 (10): 2213–21. PMID 8668348.
Downey GP, Butler JR, Brumell J, et al. (1996). "Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin.". J. Biol. Chem. 271 (35): 21005–1011. PMID 8702863.
Khoo S, Cobb MH (1997). "Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5599–604. PMID 9159118.
Li CJ, Ueda Y, Shi B, et al. (1997). "Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 8116–20. PMID 9223324.
Menegon A, Leoni C, Benfenati F, Valtorta F (1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.". Biochem. Biophys. Res. Commun. 238 (3): 800–5. doi:10.1006/bbrc.1997.7393. PMID 9325171.
Denouel-Galy A, Douville EM, Warne PH, et al. (1998). "Murine Ksr interacts with MEK and inhibits Ras-induced transformation.". Curr. Biol. 8 (1): 46–55. PMID 9427625.
Gibellini D, Bassini A, Pierpaoli S, et al. (1998). "Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells.". J. Immunol. 160 (8): 3891–8. PMID 9558095.
Duesbery NS, Webb CP, Leppla SH, et al. (1998). "Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.". Science 280 (5364): 734–7. PMID 9563949.
Ganju RK, Munshi N, Nair BC, et al. (1998). "Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.". J. Virol. 72 (7): 6131–7. PMID 9621077.
Tanimura S, Chatani Y, Hoshino R, et al. (1998). "Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering.". Oncogene 17 (1): 57–65. doi:10.1038/sj.onc.1201905. PMID 9671314.

This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.

v • d • e Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)

2.7.11	Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G Protein kinase C (Protein kinase Mζ) G-protein coupled receptor kinases (Rhodopsin, Beta adrenergic receptor) Ca2+/calmodulin-dependent (Elongation factor 2 kinase, Myosin light-chain) Phosphorylase - Cyclin-dependent Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) MAP3K - GSK-3 - AMP-activated

2.7.12	MAP2K (1, 2, 3, 4, 5, 6, 7)

2.7.1.37, or unknown	Anti-Mullerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B - PDK1

Categories: Genes on chromosome 19 | Human proteins | Chromosome 19 gene stubs | Cell signaling | Signal transduction

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MAP2K2

From Wikipedia, the free encyclopedia

[edit] References

[edit] Further reading

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