CHRNA5

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Cholinergic receptor, nicotinic, alpha 5

Identifiers

External IDs

OMIM: 118505 MGI: 87889 HomoloGene: 55485

Gene ontology
Molecular Function:	• nicotinic acetylcholine-activated cation-selective channel activity • ion channel activity • extracellular ligand-gated ion channel activity • acetylcholine receptor activity
Cellular Component:	• nicotinic acetylcholine-gated receptor-channel complex • integral to membrane • postsynaptic membrane
Biological Process:	• ion transport • signal transduction • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_000745 (mRNA)
NP_000736 (protein)

XM_973541 (mRNA)
XP_978635 (protein)

Location

Chr 15: 76.64 - 76.67 Mb

Chr 9: 54.78 - 54.81 Mb

Pubmed search

[1]

[2]

Cholinergic receptor, nicotinic, alpha 5, also known as CHRNA5, is a human gene.^[1]

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.[supplied by OMIM]^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Nicotinic acetylcholine receptor

[edit] References

^ ^a ^b Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5.

[edit] Further reading

Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function.". Rev. Physiol. Biochem. Pharmacol. 147: 1–46. doi:10.1007/s10254-003-0005-1. PMID 12783266.
Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.". Genomics 13 (4): 962–7. PMID 1505988.
Chini B, Clementi F, Hukovic N, Sher E (1992). "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. PMID 1542648.
Raimondi E, Rubboli F, Moralli D, et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits.". Genomics 12 (4): 849–50. PMID 1572664.
Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse.". Genomics 9 (2): 278–82. PMID 2004777.
Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217–28. PMID 8906617.
Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.". FEBS Lett. 400 (3): 309–14. PMID 9009220.
Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799.
Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.
Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits.". Biochem. Biophys. Res. Commun. 268 (2): 480–4. doi:10.1006/bbrc.2000.2155. PMID 10679230.
Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach.". Br. J. Pharmacol. 134 (4): 789–96. doi:10.1038/sj.bjp.0704313. PMID 11606319.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Soldà G, Boi S, Duga S, et al. (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.". Gene 345 (2): 155–64. doi:10.1016/j.gene.2004.12.005. PMID 15716100.

[edit] External links

MeSH CHRNA5+protein,+human

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v • d • e Ion channel, receptor: ligand-gated ion channels

Cys-loop receptors	5-HT/serotonin: 5-HT₃ (A) GABA: GABA A (α₁, α₂, α₃, α₄, α₅, α₆, β₁, β₂, β₃, γ₂, γ₃, δ, ε, π), GABA C (ρ₁, ρ₂) Glycine: α₁, α₂, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)₂(β2)₃, (α7)₅, Ganglion type, Muscle type)

Ionotropic glutamates	AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)

ATP-gated channels	Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)