GRIK5

From Wikipedia, the free encyclopedia

Glutamate receptor, ionotropic, kainate 5

Identifiers

GRIK5; GRIK2; EAA2; KA2

External IDs

OMIM: 600283 MGI: 95818 HomoloGene: 1578

Gene ontology
Molecular Function:	• receptor activity • ionotropic glutamate receptor activity • ion channel activity • extracellular-glutamate-gated ion channel activity • kainate selective glutamate receptor activity
Cellular Component:	• membrane • integral to membrane • postsynaptic membrane
Biological Process:	• ion transport • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002088 (mRNA)
NP_002079 (protein)

XM_989663 (mRNA)
XP_994757 (protein)

Location

Chr 19: 47.19 - 47.26 Mb

Chr 7: 24.72 - 24.78 Mb

Pubmed search

[1]

[2]

Glutamate receptor, ionotropic, kainate 5, also known as GRIK5, is a human gene.^[1]

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Kainate receptor

[edit] References

^ ^a ^b Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5.

[edit] Further reading

Kamboj RK, Schoepp DD, Nutt S, et al. (1992). "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.". Mol. Pharmacol. 42 (1): 10-5. PMID 1321949.
Szpirer C, Molné M, Antonacci R, et al. (1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 11849-53. PMID 7527545.
Cauley K, Kukekov V, Young D (1997). "Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture.". J. Neurosci. Res. 47 (3): 311-21. PMID 9039653.
Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.". Brain Res. 751 (2): 217-31. PMID 9099808.
Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485-97. PMID 9466455.
Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727-39. PMID 9808460.
Mehta S, Wu H, Garner CC, Marshall J (2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.". J. Biol. Chem. 276 (19): 16092-9. doi:10.1074/jbc.M100643200. PMID 11279111.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kohda K, Kamiya Y, Matsuda S, et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.". Brain Res. Mol. Brain Res. 110 (1): 27-37. PMID 12573530.
Hayes DM, Braud S, Hurtado DE, et al. (2003). "Trafficking and surface expression of the glutamate receptor subunit, KA2.". Biochem. Biophys. Res. Commun. 310 (1): 8-13. PMID 14511640.
Kamm C, Leung J, Joseph S, et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene.". Mov. Disord. 19 (7): 845-7. doi:10.1002/mds.20095. PMID 15254951.

[edit] External links

MeSH GRIK5+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Ion channel, receptor: ligand-gated ion channels

Cys-loop receptors	5-HT/serotonin: 5-HT₃ (A) GABA: GABA A (α₁, α₂, α₃, α₄, α₅, α₆, β₁, β₂, β₃, γ₂, γ₃, δ, ε, π), GABA C (ρ₁, ρ₂) Glycine: α₁, α₂, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)₂(β2)₃, (α7)₅, Ganglion type, Muscle type)

Ionotropic glutamates	AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)

ATP-gated channels	Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)