Alimemazine

From Wikipedia, the free encyclopedia


Alimemazine
Systematic (IUPAC) name
N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
Identifiers
CAS number	84-96-8
ATC code	D04AA10 R06 AD02, R06 AD05
PubChem	5574
DrugBank	APRD00258
Chemical data
Formula	C₁₈H₂₂N₂S
Mol. mass	298.447 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	5 hrs
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(AU)
Legal status
Routes	Oral

Alimemazine (INN), also known as trimeprazine (former BAN and USAN; trade names Nedeltran, Panectyl, Repeltin, Therafene, Theralen, Theralene, Vallergan, Vanectyl, or Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).^[1] It also acts as a sedative and anti-emetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine (Thorazine), it is not used as an anti-psychotic treatment.^[2] It is no longer available in the United States.^[3] The elimination half life is approximately 5 hours.^[4]

[edit] References

^ PubChem CID 78032.
^ Drugbank:Trimeprazine.
^ MedlinePlus:Trimeprazine.
^ Hu OY; Gfeller E, Perrin JH, Curry SH (Mar 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". J Pharm Pharmacol 38 (3): 172-6. PMID 2871150.

v • d • e Antihistamines (primarily R06)

Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine

Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine

Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)

Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine

Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide

Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)

For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine

Antiallergic agents excluding corticosteroids	Antazoline • Azelastine

Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine