SLC39A6

From Wikipedia, the free encyclopedia

Solute carrier family 39 (zinc transporter), member 6

Identifiers

External IDs

OMIM: 608731 MGI: 2147279 HomoloGene: 8199

Gene ontology
Molecular Function:	• zinc ion binding • metal ion transmembrane transporter activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• ion transport • zinc ion transport • metal ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012319 (mRNA)
NP_036451 (protein)

NM_139143 (mRNA)
NP_631882 (protein)

Location

Chr 18: 31.94 - 31.96 Mb

Chr 18: 24.72 - 24.75 Mb

Pubmed search

[1]

[2]

Solute carrier family 39 (zinc transporter), member 6, also known as SLC39A6, is a human gene.^[1]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6.

[edit] Further reading

Taylor KM, Nicholson RI (2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters.". Biochim. Biophys. Acta 1611 (1-2): 16-30. PMID 12659941.
Manning DL, Daly RJ, Lord PG, et al. (1988). "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line.". Mol. Cell. Endocrinol. 59 (3): 205-12. PMID 2903103.
Dressman MA, Walz TM, Lavedan C, et al. (2002). "Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.". Pharmacogenomics J. 1 (2): 135-41. PMID 11911440.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Taylor KM, Morgan HE, Johnson A, et al. (2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.". Biochem. J. 375 (Pt 1): 51-9. doi:10.1042/BJ20030478. PMID 12839489.
Schaner ME, Ross DT, Ciaravino G, et al. (2004). "Gene expression patterns in ovarian carcinomas.". Mol. Biol. Cell 14 (11): 4376-86. doi:10.1091/mbc.E03-05-0279. PMID 12960427.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kasper G, Weiser AA, Rump A, et al. (2005). "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients.". Int. J. Cancer 117 (6): 961-73. doi:10.1002/ijc.21235. PMID 15986450.
Zhao L, Chen W, Taylor KM, et al. (2007). "LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway.". Biochem. Biophys. Res. Commun. 363 (1): 82-8. doi:10.1016/j.bbrc.2007.08.127. PMID 17825787.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)