ABCA7

From Wikipedia, the free encyclopedia

ATP-binding cassette, sub-family A (ABC1), member 7

Identifiers

ABCA7; ABCA-SSN; ABCX; FLJ40025

External IDs

OMIM: 605414 MGI: 1351646 HomoloGene: 22783

Gene ontology
Molecular Function:	• nucleotide binding • transporter activity • ATP binding • ATPase activity
Cellular Component:	• membrane • integral to membrane • ATP-binding cassette (ABC) transporter complex
Biological Process:	• transport • phagocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019112 (mRNA)
NP_061985 (protein)

NM_013850 (mRNA)
NP_038878 (protein)

Location

Chr 19: 0.99 - 1.02 Mb

Chr 10: 79.4 - 79.42 Mb

Pubmed search

[1]

[2]

ATP-binding cassette, sub-family A (ABC1), member 7, also known as ABCA7, is a human gene.^[1]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. Alternative splicing of this gene results in two transcript variants.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

ATP-binding cassette transporter

[edit] References

^ ^a ^b Entrez Gene: ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7.

[edit] Further reading

Kaminski WE, Orsó E, Diederich W, et al. (2000). "Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7).". Biochem. Biophys. Res. Commun. 273 (2): 532–8. doi:10.1006/bbrc.2000.2954. PMID 10873640.
Niwa M, Maruyama H, Fujimoto T, et al. (2001). "Affinity selection of cDNA libraries by lambda phage surface display.". Gene 256 (1-2): 229–36. PMID 11054552.
Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene.". Biochem. Biophys. Res. Commun. 278 (3): 782–9. doi:10.1006/bbrc.2000.3880. PMID 11095984.
Tanaka AR, Ikeda Y, Abe-Dohmae S, et al. (2001). "Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome.". Biochem. Biophys. Res. Commun. 283 (5): 1019–25. doi:10.1006/bbrc.2001.4891. PMID 11355874.
Broccardo C, Osorio J, Luciani MF, et al. (2001). "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter.". Cytogenet. Cell Genet. 92 (3-4): 264–70. PMID 11435699.
Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.". J. Hum. Genet. 47 (6): 285–310. doi:10.1007/s100380200041. PMID 12111378.
Wang N, Lan D, Gerbod-Giannone M, et al. (2003). "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.". J. Biol. Chem. 278 (44): 42906–12. doi:10.1074/jbc.M307831200. PMID 12917409.
Kielar D, Kaminski WE, Liebisch G, et al. (2003). "Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization.". J. Invest. Dermatol. 121 (3): 465–74. doi:10.1046/j.1523-1747.2003.12404.x. PMID 12925201.
Abe-Dohmae S, Ikeda Y, Matsuo M, et al. (2004). "Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.". J. Biol. Chem. 279 (1): 604–11. doi:10.1074/jbc.M309888200. PMID 14570867.
Ikeda Y, Abe-Dohmae S, Munehira Y, et al. (2004). "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.". Biochem. Biophys. Res. Commun. 311 (2): 313–8. PMID 14592415.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Hayashi M, Abe-Dohmae S, Okazaki M, et al. (2005). "Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7.". J. Lipid Res. 46 (8): 1703–11. doi:10.1194/jlr.M500092-JLR200. PMID 15930518.
Jehle AW, Gardai SJ, Li S, et al. (2006). "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.". J. Cell Biol. 174 (4): 547–56. doi:10.1083/jcb.200601030. PMID 16908670.

[edit] External links

MeSH ABCA7+protein,+human

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)