Hyperpituitarism
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Hyperpituitarism Classification and external resources |
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ICD-10 | E22. |
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ICD-9 | 253.1 |
eMedicine | ped/1092 |
MeSH | D006964 |
This article does not cite any references or sources. (January 2007) Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed. |
Hyperpituitarism is the result of excess secretion of adenohypophyseal trophic hormones most commonly by a functional pituitary adenoma. Other causes are hyperplasias and carcinomas of the adenohypophysis, secretion by non-pituitary tumours and certain hypothalamic disorders.
[edit] Clinical manifestations
Depending on the cell type(s) affected, clinical manifestations of hormone excess may include:
- Hyperprolactinaemia
- Cushing's disease
- Precocious puberty
- Gigantism or Acromegaly
- Hyperthyroidism (rare)
[edit] Associated conditions
When there is an enlargement of the pituitary tissue, hyperpituitarism is often associated with:
- Visual field defects, classically bitemporal hemianopia
- Radiographic abnormalities of the sella turcica, such as sellar expansion, bony erosion and disuption of the diaphragma sellae
- Increased intracranial pressure
[edit] Symptoms
Symptoms caused by hormone excess and associated mass effects include:
- Headache
- Visual field loss or Double vision
- Excessive sweating
- Hoarseness
- Milk secretion from breast
- Sleep apnea
- Carpal tunnel syndrome
- Joint pain and limitation of motion
- Muscle weakness
- Numbness or tingling of skin
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