Hashimoto's thyroiditis
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| Hashimoto's thyroiditis Classification and external resources |
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| Histology | |
| ICD-10 | E06.3 |
| ICD-9 | 245.2 |
| OMIM | 140300 |
| DiseasesDB | 5649 |
| eMedicine | med/949 |
| MeSH | D050031 |
Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease where the body's own T-cells attack the cells of the thyroid. It was the first disease to be recognised as an autoimmune disease.
This disorder is believed to be the most common cause of primary hypothyroidism in North America. It occurs far more often in women than in men (10:1 to 20:1), and is most prevalent between 45 and 65 years of age.
In European countries, an atrophic form of autoimmune thyroiditis (Ord's thyroiditis) is more common than Hashimoto's thyroiditis.
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[edit] Causes
A family history of thyroid disorders is common, with the HLA-DR5 gene most strongly implicated conferring a relative risk of 3 in the UK.
The genes implicated vary in different ethnic groups and the incidence is increased in patients with chromosomal disorders, including Turner, Down's, and Klinefelter's syndromes.
The underlying specifics of the immune system destruction of thyroid cells is not clearly understood. Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of patients may have none of these antibodies present. A percentage of the population may also have these antibodies without developing Hashimoto's thyroiditis.
[edit] Presentation
In many cases, Hashimoto's thyroiditis results in hypothyroidism, although in its acute phase, it can cause a transient hyperthyroidism thyrotoxic state known as hashitoxicosis.
Physiologically, antibodies against thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterised by invasion of the thyroid tissue by leukocytes, mainly T-lymphocytes. It is associated with non-Hodgkin lymphoma.
Symptoms of Hashimoto's thyroiditis might include symptoms of hyperthyroidism in the early phase of the disease, and then hypothyroidism. Weight gain, weight loss, depression, mania, fatigue, panic attacks, bradycardia, tachycardia, high cholesterol, reactive hypoglycemia, constipation, migraines, memory loss, infertility and hair loss are a few possible symptoms.
[edit] Treatment
Hypothyroidism caused by Hashimoto's Thyroiditis is treated with thyroid hormone replacement. A small pill taken once a day should be able to keep the thyroid hormone levels normal. This medicine will, in most cases, need to be taken for the rest of the patient's life.
[edit] Eponym
Also known as Hashimoto's disease, Hashimoto's thyroiditis is named after the Japanese physician Hashimoto Hakaru (1881−1934) of the medical school at Kyushu University,[1] who first described the symptoms in 1912 in a German publication[2].
[edit] Symptoms
Common symptoms in people with thyroiditis are:
- Enlarged thyroid area
- Weight loss or weight gain
- Frequent nausea
[edit] Possible complications
If untreated for an extended period, Hashimoto's thyroiditis may lead to muscle failure, including possible heart failure.
[edit] References
- ^ Hakaru Hashimoto at Who Named It
- ^ H. Hashimoto: Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Archiv für klinische Chirurgie, Berlin, 1912, 97: 219−248.
[edit] External links
- Hashimoto's disease at the Mayo Clinic
- Hashimoto's Thyroiditis
- Thyroid Autoimmunity at AHSTA Resources
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