Sulfatase
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Steryl-sulfatase | ||
Identifiers | ||
---|---|---|
Symbol | Sulfatase | |
Pfam | PF00884 | |
InterPro | IPR000917 | |
PROSITE | PDOC00117 | |
SCOP | 1auk | |
OPM family | 24 | |
OPM protein | 1p49 | |
Available PDB structures:
1fsu :43-486 1hdhB:3-501 1p49A:25-514 1n2kA:19-440 1e3cP:19-440 1e2sP:19-440 1e1zP:19-440 2aikP:68-74 1e33P:19-440 1auk :19-440 1n2lA:19-440 |
Sulfatases EC 3.1.6. are esterase enzymes which remove sulfate from a variety of substrates by hydrolyzing various sulfate esters.
The following sulfatases were shown to be structurally related based on their sequence homology:[1][2][3]
- cerebroside-sulfatase
- steryl-sulfatase
- arylsulfatase A EC 3.1.6.8 (ASA), a lysosomal enzyme which hydrolyzes cerebroside sulfate;
- arylsulfatase B EC 3.1.6.12 (ASB) which hydrolyzes the sulfate ester group from N-acetylgalactosamine 4-sulfate residues of dermatan sulfate;
- arylsulfatase C (ASD) and E (ASE); steryl-sulfatase EC 3.1.6.2 (STS), a membrane bound enzyme which hydrolyzes 3-beta-hydroxy steroid sulfates;
- iduronate 2-sulfatase EC 3.1.6.13 (IDS), a lysosomal enzyme that hydrolyzes the 2-sulfate groups from iduronic acids in dermatan sulfate and heparan sulfate;
- N-acetylgalactosamine-6-sulfatase EC 3.1.6.4, which hydrolyzes the 6-sulfate groups of the N-acetyl-D-galactosamine of chondroitin sulfate and D-galactose 6-sulfate units of keratan sulfate;
- N-sulfoglucosamine sulfohydrolase EC 3.10.1.1, the lysosomal enzyme that hydrolyses N-sulfo-D-glucosamine into glucosamine and sulfate;
- glucosamine-6-sulfatase EC 3.1.6.14 (G6S), which hydrolyzes the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate;
- N-sulfoglucosamine sulfohydrolase EC 3.10.1.1, the lysosomal enzyme that hydrolyses N-sulfo-D-glucosamine into glucosamine and sulfate;
- sea urchin embryo arylsulfatase EC 3.1.6.1;
- green algae arylsulfatase EC 3.1.6.1, which plays a role in the mineralization of sulfates; and
- arylsulfatase EC 3.1.6.1 from Escherichia coli, Klebsiella aerogenes and Pseudomonas aeruginosa.
[edit] Human proteins containing this domain
ARSA; ARSB; ARSD; ARSE; ARSF; ARSG; ARSH; ARSI; ARSJ; ARSK; GALNS; GNS; IDS; PIGG; SGSH; STS; SULF1; SULF2;
[edit] References
- ^ von Figura K, Vingron M, Schmidt B, Meyer HE, Peters C, Rommerskirch W, Rupp K, Pohlmann R, Zuhlsdorf M (1990). "Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B". J. Biol. Chem. 265 (6): 3374–3381. PMID 2303452.
- ^ Wilson PJ, Morris CP, Anson DS, Occhiodoro T, Bielicki J, Clements PR, Hopwood JJ (1990). "Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8531–8535. doi: . PMID 2122463.
- ^ Grossman AR, de Hostos EL, Schilling J (1989). "Structure and expression of the gene encoding the periplasmic arylsulfatase of Chlamydomonas reinhardtii". Mol. Gen. Genet. 218 (2): 229–239. doi: . PMID 2476654.
[edit] External links
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This article includes text from the public domain Pfam and InterPro IPR000917