Silodosin

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Silodosin
Systematic (IUPAC) name
1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-7-indolinecarboxamide
Identifiers
CAS number	160970-54-7
ATC code	?
PubChem	5312125
Chemical data
Formula	C₂₅H₃₃F₃N₃O₄
Mol. mass	495.534g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Silodosin is an α₁-adrenoceptor antagonist with high uroselectivity. It appears to be more effective than tamsulosin in relieving urinary symptoms associated with benign prostatic hyperplasia (BPH).

[edit] History

Silodosin received its first marketing approval in Japan in May 2006 under the tradename Urief, which is jointly marketed by Kissei Pharmaceutical Co., Ltd. and Daiichi Sankyo Pharmaceutical Co., Ltd.

Kissei licensed the US, Canadian, and Mexican rights for silodosin to Watson Pharmaceuticals, Inc. in 2004.

On February 12, 2008, Watson announced that the New Drug Application submitted to the United States Food and Drug Administration for silodosin has been accepted for filing. Watson expects FDA action on silodosin by the fourth quarter of 2008. ^[1]

[edit] References

^ Drugs.com, Watson Announces Silodosin NDA Accepted for Filing by FDA for the Treatment of Benign Prostatic Hyperplasia. Retrieved on 2008-02-13.

[edit] External links

v • d • e Urologicals (G04)

Acidifiers	Ammonium chloride, Calcium chloride

Urinary antispasmodics (primarily antimuscarinics)	Darifenacin, Emepronium, Fenoverine, Fesoterodine, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium

For erectile dysfunction	prostaglandins: Alprostadil PDE5 inhibitors: Avanafil - Sildenafil - Tadalafil - Udenafil - Vardenafil alpha blockers: Moxisylyte - Phentolamine - Yohimbine others: Apomorphine - Papaverine

Other urologicals	Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Pentosan polysulfate, Phenazopyridine, Phenyl salicylate, Succinimide

For benign prostatic hypertrophy	5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Silodosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Serenoa repens