Nuclear receptor coactivator 2

From Wikipedia, the free encyclopedia

Identifiers

NCOA2; GRIP1; MGC138808; NCoA-2; TIF2

External IDs

OMIM: 601993 MGI: 1276533 HomoloGene: 4768

Gene ontology
Molecular Function:	• signal transducer activity • receptor binding • transcription repressor activity • thyroid hormone receptor coactivator activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-dependent • signal transduction • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006540 (mRNA)
NP_006531 (protein)

NM_001077695 (mRNA)
NP_001071163 (protein)

Location

Chr 8: 71.2 - 71.48 Mb

Chr 1: 13.13 - 13.36 Mb

Pubmed search

[1]

[2]

The nuclear receptor coactivator 2 (NCOA2) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA2 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA2 assists nuclear receptors in the upregulation of DNA expression.^[1]^[2]

NCOA2 is also frequently called glucocorticoid receptor interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

[edit] References

^ Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors". EMBO J 15 (14): 3667–75. PMID 8670870.
^ Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol Cell Biol 17 (5): 2735–44. PMID 9111344.

[edit] Further reading

Voegel JJ, Heine MJ, Zechel C, et al. (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.". EMBO J. 15 (14): 3667–75. PMID 8670870.
Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors.". Mol. Cell. Biol. 17 (5): 2735–44. PMID 9111344.
Voegel JJ, Heine MJ, Tini M, et al. (1998). "The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.". EMBO J. 17 (2): 507–19. doi:10.1093/emboj/17.2.507. PMID 9430642.
Carapeti M, Aguiar RC, Goldman JM, Cross NC (1998). "A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.". Blood 91 (9): 3127–33. PMID 9558366.
Fryer CJ, Archer TK (1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.". Nature 393 (6680): 88–91. doi:10.1038/30032. PMID 9590696.
Berrevoets CA, Doesburg P, Steketee K, et al. (1998). "Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2).". Mol. Endocrinol. 12 (8): 1172–83. PMID 9717843.
Wang JC, Stafford JM, Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.". J. Biol. Chem. 273 (47): 30847–50. PMID 9812974.
Hong H, Darimont BD, Ma H, et al. (1999). "An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors.". J. Biol. Chem. 274 (6): 3496–502. PMID 9920895.
Chen D, Ma H, Hong H, et al. (1999). "Regulation of transcription by a protein methyltransferase.". Science 284 (5423): 2174–7. PMID 10381882.
Ma H, Hong H, Huang SM, et al. (1999). "Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins.". Mol. Cell. Biol. 19 (9): 6164–73. PMID 10454563.
Atkins GB, Hu X, Guenther MG, et al. (1999). "Coactivators for the orphan nuclear receptor RORalpha.". Mol. Endocrinol. 13 (9): 1550–7. PMID 10478845.
Carrero P, Okamoto K, Coumailleau P, et al. (2000). "Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.". Mol. Cell. Biol. 20 (1): 402–15. PMID 10594042.
Xie W, Hong H, Yang NN, et al. (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2.". Mol. Endocrinol. 13 (12): 2151–62. PMID 10598588.
Naltner A, Ghaffari M, Whitsett JA, Yan C (2000). "Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.". J. Biol. Chem. 275 (1): 56–62. PMID 10617585.
Jimenez-Lara AM, Heine MJ, Gronemeyer H (2000). "Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family.". FEBS Lett. 468 (2-3): 203–10. PMID 10692587.
Poelzl G, Kasai Y, Mochizuki N, et al. (2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2836–9. doi:10.1073/pnas.050580997. PMID 10706629.
Herdick M, Steinmeyer A, Carlberg C (2000). "Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators.". J. Biol. Chem. 275 (22): 16506–12. doi:10.1074/jbc.M910000199. PMID 10748178.
Kodera Y, Takeyama K, Murayama A, et al. (2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators.". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
Koh SS, Chen D, Lee YH, Stallcup MR (2001). "Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities.". J. Biol. Chem. 276 (2): 1089–98. doi:10.1074/jbc.M004228200. PMID 11050077.
Park JJ, Irvine RA, Buchanan G, et al. (2000). "Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor.". Cancer Res. 60 (21): 5946–9. PMID 11085509.

[edit] External links

MeSH nuclear+receptor+coactivator+2

This biochemistry article is a stub. You can help Wikipedia by expanding it.

v • d • e Transcription coregulators

Coactivators	ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1 NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)

Corepressors	Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33) NCOR1 - NCOR2 (SMRT)

ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex - SWI/SNF