Nuclear receptor co-repressor 1

From Wikipedia, the free encyclopedia

Identifiers

NCOR1; KIAA1047; MGC104216; N-CoR; TRAC1; hCIT529I10; hN-CoR

External IDs

OMIM: 600849 MGI: 1349717 HomoloGene: 38166

Gene ontology
Molecular Function:	• DNA binding • transcription corepressor activity • receptor activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription from RNA polymerase II promoter • chromatin modification • regulation of transcription • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001133522 (mRNA)
XP_001133522 (protein)

NM_011308 (mRNA)
NP_035438 (protein)

Location

Chr 17: 15.88 - 16.06 Mb

n/a

Pubmed search

[1]

[2]

The nuclear receptor co-repressor 1 (NCOR1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.^[1]^[2]

NCOR1 is also sometimes referred to as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1).

[edit] External links

MeSH nuclear+receptor+corepressor+1

[edit] References

^ Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG (1998). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114.
^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci U S A 95 (18): 10860–5. doi:10.1073/pnas.95.18.10860. PMID 9724795.

[edit] Further reading

Minucci S, Pelicci PG (1999). "Retinoid receptors in health and disease: co-regulators and the chromatin connection.". Semin. Cell Dev. Biol. 10 (2): 215–25. doi:10.1006/scdb.1999.0303. PMID 10441075.
Hörlein AJ, Näär AM, Heinzel T, et al. (1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.". Nature 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114.
Downes M, Burke LJ, Bailey PJ, Muscat GE (1997). "Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.". Nucleic Acids Res. 24 (22): 4379–86. PMID 8948627.
Tagami T, Madison LD, Nagaya T, Jameson JL (1997). "Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone.". Mol. Cell. Biol. 17 (5): 2642–8. PMID 9111334.
Zamir I, Dawson J, Lavinsky RM, et al. (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. PMID 9405624.
Burke LJ, Downes M, Laudet V, Muscat GE (1998). "Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.". Mol. Endocrinol. 12 (2): 248–62. PMID 9482666.
Guidez F, Ivins S, Zhu J, et al. (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.". Blood 91 (8): 2634–42. PMID 9531570.
Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. (1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.". Genes Dev. 12 (15): 2269–77. PMID 9694793.
Laherty CD, Billin AN, Lavinsky RM, et al. (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.". Mol. Cell 2 (1): 33–42. PMID 9702189.
Wang J, Hoshino T, Redner RL, et al. (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. PMID 9724795.
Ordentlich P, Downes M, Xie W, et al. (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. PMID 10077563.
Dowell P, Ishmael JE, Avram D, et al. (1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein.". J. Biol. Chem. 274 (22): 15901–7. PMID 10336495.
Boutell JM, Thomas P, Neal JW, et al. (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.". Hum. Mol. Genet. 8 (9): 1647–55. PMID 10441327.
Nagaya T, Chen KS, Fujieda M, et al. (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2.". Genomics 59 (3): 339–41. doi:10.1006/geno.1998.5694. PMID 10444336.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.
Hu X, Lazar MA (1999). "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.". Nature 402 (6757): 93–6. doi:10.1038/47069. PMID 10573424.
Huang EY, Zhang J, Miska EA, et al. (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.". Genes Dev. 14 (1): 45–54. PMID 10640275.
Morohoshi F, Mitani S, Mitsuhashi N, et al. (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.". Gene 241 (2): 287–95. PMID 10675041.
Masselink H, Bernards R (2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.". Oncogene 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.

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v • d • e Transcription coregulators

Coactivators	ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1 NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)

Corepressors	Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33) NCOR1 - NCOR2 (SMRT)

ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex - SWI/SNF