Methyprylon

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Methyprylon
Systematic (IUPAC) name
3,3-diethyl-5-methylpiperidine-2,4-dione
Identifiers
CAS number	125-64-4
ATC code	N05CE02
PubChem	4162
DrugBank	APRD00734
Chemical data
Formula	C10H17NO2
Mol. mass	183.248 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	60%
Metabolism	?
Half life	6-16 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Methyprylon is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with less side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1965 and the Canadian market in September 1990.

Side effects can include: Skin rash, fever, depression, ulcers or sores in mouth or throat, unusual bleeding or bruising, confusion, fast heartbeat, respiratory depression, swelling of feet or lower legs, dizziness, drowsiness, headache, double vision, clumsiness, constipation, diarrhea, nausea, vomiting, unusual weakness

[edit] External links

• Contos D, Dixon K, Guthrie R, Gerber N, Mays D (1991). "Nonlinear elimination of methyprylon (noludar) in an overdosed patient: correlation of clinical effects with plasma concentration.". J Pharm Sci 80 (8): 768–71. doi:10.1002/jps.2600800813. PMID 1686463. 
• Gwilt P, Pankaskie M, Thornburg J, Zustiak R, Shoenthal D (1985). "Pharmacokinetics of methyprylon following a single oral dose.". J Pharm Sci 74 (9): 1001–3. doi:10.1002/jps.2600740920. PMID 2866242. 
• Lomen P, Linet O (1976). "Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients.". J Int Med Res 4 (1): 55–8. PMID 16792. 

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