Melperone

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Melperone
Systematic (IUPAC) name
1-(4-fluorophenyl)-4-(4-methyl-1-piperidyl)butan-1-one
Identifiers
CAS number	3575-80-2
ATC code	N05AD03
PubChem	15387
Chemical data
Formula	C₁₆H₂₂F N O
Mol. mass	263.35 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic (inhibits CYP2D6^[1])
Half life	3–4 hours (oral) 6 hours (IM)
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, intramuscular injection

Melperone (INN, also known as methylperone) is a butyrophenone atypical antipsychotic. It is sold under the trade names Buronil, Burnil, and Eunerpan.

[edit] Chemistry

Appearance: White, crystalline odorless powder
Solubility: Freely soluble in water. Freely soluble in ethanol 99.5% and chloroform. Practically insoluble in diethyl ether.
Melting Point: 205-210C
pH (1% in water): 4.5-6.5
Stability: 48 months

It is a white crystalline powder that is manufactured by Dupont Chemoswed (Sweden). It is a butyrophenone (1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride).

[edit] References

^ Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). "Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine". Pharmacopsychiatry 36 (1): 3–6. doi:10.1055/s-2003-38084. PMID 12649767.

[edit] External links

v • d • e Psycholeptics: antipsychotics (N05A)

Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine

Other typical antipsychotics	Indoles (Molindone) Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) other (Loxapine)

Atypical antipsychotics	Butyrophenones (Melperone) Indoles (Sertindole, Ziprasidone) Benzamides (Sulpiride, Remoxipride, Amisulpride) diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)