From Wikipedia, the free encyclopedia
Guanine nucleotide binding protein (G protein), q polypeptide, also known as GNAQ, is a human gene.
Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM][1]
[edit] References
[edit] Further reading
- Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. PMID 11916537.
- Van Oekelen D, Luyten WH, Leysen JE (2003). "5-HT2A and 5-HT2C receptors and their atypical regulation properties.". Life Sci. 72 (22): 2429–49. PMID 12650852.
- Lesch KP, Manji HK (1992). "Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain.". Biol. Psychiatry 32 (7): 549–79. PMID 1333286.
- Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.". Biochem. J. 312 ( Pt 1): 151–8. PMID 7492305.
- Blin N, Yun J, Wess J (1995). "Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor.". J. Biol. Chem. 270 (30): 17741–8. PMID 7629074.
- Kabouridis PS, Waters ST, Escobar S, et al. (1995). "Expression of GTP-binding protein alpha subunits in human thymocytes.". Mol. Cell. Biochem. 144 (1): 45–51. PMID 7791744.
- Allgeier A, Offermanns S, Van Sande J, et al. (1994). "The human thyrotropin receptor activates G-proteins Gs and Gq/11.". J. Biol. Chem. 269 (19): 13733–5. PMID 8188646.
- Wedegaertner PB, Chu DH, Wilson PT, et al. (1993). "Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.". J. Biol. Chem. 268 (33): 25001–8. PMID 8227063.
- Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.". Endocrinology 132 (6): 2484–90. PMID 8504751.
- Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. PMID 8552586.
- Denker SP, McCaffery JM, Palade GE, et al. (1996). "Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas.". J. Cell Biol. 133 (5): 1027–40. PMID 8655576.
- Chen B, Leverette RD, Schwinn DA, Kwatra MM (1996). "Human G(alpha q): cDNA and tissue distribution.". Biochim. Biophys. Acta 1281 (2): 125–8. PMID 8664309.
- Dong Q, Shenker A, Way J, et al. (1997). "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.". Genomics 30 (3): 470–75. doi:10.1006/geno.1995.1267. PMID 8825633.
- Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.". Biochem. J. 318 ( Pt 3): 1023–31. PMID 8836152.
- Gomeza J, Mary S, Brabet I, et al. (1996). "Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.". Mol. Pharmacol. 50 (4): 923–30. PMID 8863838.
- Petit A, Geoffroy P, Bélisle S (1997). "Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta.". J. Soc. Gynecol. Investig. 3 (6): 316–21. PMID 8923415.
- Petit A, Geoffroy P, Bélisle S (1997). "Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension.". Life Sci. 60 (12): 953–60. PMID 9061052.
- Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.
- Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.". FEBS Lett. 407 (3): 257–60. PMID 9175863.
- Gabbeta J, Yang X, Kowalska MA, et al. (1997). "Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8750–5. PMID 9238049.
