GNAI1

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

PDB rendering based on 1agr.

Available structures: 1agr, 1as0, 1as2, 1as3, 1bh2, 1bof, 1cip, 1gdd, 1gfi, 1gg2, 1gia, 1gil, 1git, 1gp2, 1kjy, 1svk, 1svs, 1y3a, 2g83, 2gtp, 2hlb, 2ihb, 2ik8, 2ode

Identifiers

Symbol(s)

GNAI1; Gi

External IDs

OMIM: 139310 MGI: 95771 HomoloGene: 74417

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • signal transducer activity • protein binding • GTP binding
Cellular Component:	• heterotrimeric G-protein complex • plasma membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002069 (mRNA)
NP_002060 (protein)

NM_010305 (mRNA)
NP_034435 (protein)

Location

Chr 7: 79.6 - 79.69 Mb

Chr 5: 17.78 - 17.87 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1, also known as GNAI1, is a human gene.^[1]

[edit] References

^ Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.

[edit] Further reading

Sidhu A, Niznik HB (2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins.". Int. J. Dev. Neurosci. 18 (7): 669-77. PMID 10978845.
Brown EJ, Frazier WA (2001). "Integrin-associated protein (CD47) and its ligands.". Trends Cell Biol. 11 (3): 130-5. PMID 11306274.
Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179-212. PMID 11916537.
Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907-11. PMID 1902575.
Gennity JM, Siess W (1991). "Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.". Biochem. J. 279 ( Pt 3): 643-50. PMID 1953657.
Itoh H, Toyama R, Kozasa T, et al. (1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.". J. Biol. Chem. 263 (14): 6656-64. PMID 2834384.
Bray P, Carter A, Guo V, et al. (1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein.". Proc. Natl. Acad. Sci. U.S.A. 84 (15): 5115-9. PMID 3110783.
Bloch DB, Bloch KD, Iannuzzi M, et al. (1988). "The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.". Am. J. Hum. Genet. 42 (6): 884-8. PMID 3130752.
Nagata K, Katada T, Tohkin M, et al. (1988). "GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin.". FEBS Lett. 237 (1-2): 113-7. PMID 3139448.
Kagimoto S, Yamada Y, Kubota A, et al. (1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.". Biochem. Biophys. Res. Commun. 202 (2): 1188-95. doi:10.1006/bbrc.1994.2054. PMID 7914078.
Nitta K, Uchida K, Kawashima A, et al. (1994). "Identification of GTP-binding proteins in human glomeruli.". Nippon Jinzo Gakkai shi 36 (1): 9-12. PMID 8107314.
Law SF, Zaina S, Sweet R, et al. (1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.". Mol. Pharmacol. 45 (4): 587-90. PMID 8183236.
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.". Endocrinology 132 (6): 2484-90. PMID 8504751.
Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116-20. PMID 8552586.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272-9. PMID 8626678.
De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203-8. PMID 8986788.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216-20. PMID 9207071.
Shuey DJ, Betty M, Jones PG, et al. (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.". J. Neurochem. 70 (5): 1964-72. PMID 9572280.

This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.

v • d • e Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)

3.6.5.1: Heterotrimeric G protein	G_αs - G_αi (GNAI1, GNAI2, GNAI3) - G_αq/11 (GNAQ, GNA11) - G_α12/13 (GNA12, GNA13) - Transducin (GNAT1, GNAT2)

3.6.5.2: Small GTPase > Ras superfamily	Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho family (RhoA, RhoB, CDC42, Rac1) - Rap

3.6.5.3: Elongation factor	Prokaryotic - Eukaryotic

3.6.5.5-6: Other	Dynamin (is a GTPase, is not a G protein) - Tubulin

Categories: Genes on chromosome 7 | Human proteins | Chromosome 7 gene stubs

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GNAI1

From Wikipedia, the free encyclopedia

[edit] References

[edit] Further reading

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