Demecarium bromide

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Demecarium bromide
Systematic (IUPAC) name
trimethyl-[3-[methyl-[10-[methyl- (3-trimethylammoniophenoxy) carbonyl-amino] decyl] carbamoyl] oxyphenyl]-ammonium dibromide
Identifiers
CAS number	56-94-0
ATC code	S01EB04
PubChem	5965
DrugBank	APRD00905
Chemical data
Formula	C₃₂H₅₂Br₂N₄O₄
Mol. mass	716.588 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

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Demecarium bromide is a compound classified by the World Health Organization as a parasympathomimetic.^{[citation needed]} Demecarium bromide is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals.

[edit] See also

[edit] External links

Ward D, Abney K, Oliver J (2003). "The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs.". Vet Ophthalmol 6 (1): 23–5. doi:10.1046/j.1463-5224.2003.00257.x. PMID 12641839.
Krohne S (1994). "Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs.". Am J Vet Res 55 (12): 1729–33. PMID 7887518.
Gum G, Gelatt K, Gelatt J, Jones R (1993). "Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma.". Am J Vet Res 54 (2): 287–93. PMID 8430939.

v • d • e Ophthalmologicals: antiglaucoma preparations and miotics (S01E)

Sympathomimetics	Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine

Parasympathomimetics	Aceclidine • Acetylcholine • Carbachol • Demecarium • Echothiophate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon • Pilocarpine

Carbonic anhydrase inhibitors	Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide

Beta blocking agents	Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol

Prostaglandin analogues	Bimatoprost • Latanoprost • Travoprost • Unoprostone

Other agents	Dapiprazole • Guanethidine