Cefoperazone

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Cefoperazone
Systematic (IUPAC) name
(6R,7S)-7-{[2-[(4-ethyl-2,3-dioxo-piperazine-1- carbonyl)amino]-2-(4-hydroxyphenyl)acetyl}amino]- 3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number	62893-19-0
ATC code	J01DD12 J01 DD62
PubChem	44185
Chemical data
Formula	C₂₅H₂₇N₉O₈S₂
Mol. mass	645.67 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	Hepatic
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Cefoperazone is a third generation cephalosporin antibiotic, marketed by pfizer under the name Cefobid.

Cefina-SB is a combination of sulbactam and cefoperazone. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase producing organisms. Cefina-SB is available as injection for the treatment of bacterial infections. In some countries, the combination is sold as Sulperazone. Cefoperazone is available in the United States as Cefobid.

It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D)

First generation	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole

Second generation	Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime

Third generation	Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Flomoxef, Latamoxef

Fourth generation	Cefepime, Cefozopran, Cefpirome, Cefquinome

Fifth generation	Ceftobiprole

Other beta-lactam antibacterials	Monobactams (Aztreonam), Carbapenems (Parenteral - Doripenem, Ertapenem, Imipenem, Meropenem, Panipenem, Oral - Faropenem)