Cefixime

From Wikipedia, the free encyclopedia


Cefixime
Systematic (IUPAC) name
(6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxy methoxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number	79350-37-1
ATC code	J01DD08
PubChem	54362
DrugBank	APRD00583
Chemical data
Formula	C₁₆H₁₅N₅O₇S₂
Mol. mass	453.452 g/mol
Pharmacokinetic data
Bioavailability	40% to 50%
Protein binding	Approximately 60%
Metabolism	?
Half life	Variable Average 3 to 4 hours
Excretion	Renal and biliary
Therapeutic considerations
Pregnancy cat.	B
Legal status
Routes	Oral

Cefixime is an oral third generation cephalosporin antibiotic. It was sold under the trade name Suprax in the USA, until 2003 when it was taken off the market by drug manufacturer Wyeth after its patent expired. The oral suspension form of "Suprax" was re-launched by Lupin in the USA. Cefixime is still available in Canada. It is used to treat gonorrhea^[1], tonsilitis^[2], and pharyngitis^[2].

[edit] References

^ McMillan A, Young H. (2007). "The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime.". Int J STD AIDS 18 (4): 253-4. doi:10.1258/095646207780658971. PMID 17509176.
^ ^a ^b Adam D, Hostalek U, Tröster K. (1995). "5-day cefixime therapy for bacterial pharyngitis and/or tonsillitis: comparison with 10-day penicillin V therapy.". Infection 23 (Suppl 2): S83-6. doi:10.1007/BF01742990. PMID 8537138.

[edit] External links

Suprax Online - Information about cefixime.
Notice to Readers: Discontinuation of Cefixime Tablets --- United States - A FDA report alerting physicians about the discontinuation of cefixime.

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D)

First generation	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole

Second generation	Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime

Third generation	Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Flomoxef, Latamoxef

Fourth generation	Cefepime, Cefozopran, Cefpirome, Cefquinome

Fifth generation	Ceftobiprole

Other beta-lactam antibacterials	Monobactams (Aztreonam), Carbapenems (Parenteral - Doripenem, Ertapenem, Imipenem, Meropenem, Panipenem, Oral - Faropenem)