Angiopoietin

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angiopoietin 1
Identifiers
Symbol	ANGPT1
Entrez	284
HUGO	484
OMIM	601667
RefSeq	NM_001146
UniProt	Q15389
Other data
Locus	Chr. 8 q22.3-8q23

angiopoietin 2
Identifiers
Symbol	ANGPT2
Entrez	285
HUGO	485
OMIM	601922
RefSeq	NM_001147
UniProt	O15123
Other data
Locus	Chr. 8 p23

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. Ang1 and Ang2 are required for the formation of mature blood vessels, as demonstrated by mouse knock out studies ^[1].

Contents 1 Angiopoietin Receptors 2 Clinical Relevance 3 References 4 External links

[edit] Angiopoietin Receptors

The Tie receptors are tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating the binding and activation of downstream, intracellular enzymes; this process is called cell signalling, and it is the method by which cells are induced to activate or inhibit key regulatory functions. It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation - but it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins

[edit] Clinical Relevance

Angiopoietin 2 is elevated in patients with angiosarcoma (PMID 15149523)

[edit] References

1. ^ Thurston G. Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis. Cell Tissue Res. 2003 Oct;314(1):61-8. Epub 2003 Aug 12.

[edit] External links

• MeSH Angiopoietins

v • d • e Proteins: angiogenesis angiogenic Angiopoietin (ANGPT1, ANGPT2) - Vascular endothelial growth factor (A, B, C, D, PGF) anti-angiogenic Angiostatin - Endostatin