Adrenomedullin receptor

From Wikipedia, the free encyclopedia

Identifiers

ADMR; 7TMR; AMR; MGC34399; gamrh; hrhAMR

External IDs

OMIM: 605307 MGI: 109545 HomoloGene: 5255

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007264 (mRNA)
NP_009195 (protein)

NM_007412 (mRNA)
NP_031438 (protein)

Location

Chr 12: 55.67 - 55.68 Mb

n/a

Pubmed search

[1]

[2]

Adrenomedullin receptor is a receptor. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin.^[1] adrenomedullin. It is encoded by the human gene ADMR.^[1]

1 Structure
2 Mechanism
3 References
4 Further reading

[edit] Structure

The structure of the adrenomedullin receptor is a calcitonin receptor-like receptor (CL) linked to the second of three single transmembrane domain receptor activity-modifying proteins (RAMPs), i.e. RAMP2, which is essential for functional activity. It is worth noting that unlike the classical one ligand-one receptor notion of receptor signalling, the interaction of both CL and RAMP at the membrane, is required for AM to mediate its action.

[edit] Mechanism

The outcome of AM stimulatation of its receptor is activation of the G protein G_s^[2], resulting in cellular production of both cyclic AMP (cAMP). The activated adrenomedullin receptor also produces nitric oxide production. Some may find the production of these inside the cell to be at odds, since often they have opposing effects, but as yet, the timing of these effects remains to be studied.

[edit] References

[edit] Further reading

Lah JJ, Frishman WH (2002). "Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential.". Heart disease (Hagerstown, Md.) 2 (3): 259–65. PMID 11728267.
Mukoyama M, Sugawara A, Nagae T, et al. (2002). "Role of adrenomedullin and its receptor system in renal pathophysiology.". Peptides 22 (11): 1925–31. PMID 11754983.
Fowler DE, Wang P (2002). "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).". Int. J. Mol. Med. 9 (5): 443–9. PMID 11956648.
Kato J, Kitamura K, Kangawa K, Eto T (1995). "Receptors for adrenomedullin in human vascular endothelial cells.". Eur. J. Pharmacol. 289 (2): 383–5. PMID 7621913.
Martínez A, Miller MJ, Catt KJ, Cuttitta F (1997). "Adrenomedullin receptor expression in human lung and in pulmonary tumors.". J. Histochem. Cytochem. 45 (2): 159–64. PMID 9016306.
Hänze J, Dittrich K, Dötsch J, Rascher W (1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.". Biochem. Biophys. Res. Commun. 240 (1): 183–8. doi:10.1006/bbrc.1997.7631. PMID 9367907.
Martínez A, Elsasser TH, Muro-Cacho C, et al. (1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument.". Endocrinology 138 (12): 5597–604. PMID 9389548.
Kennedy SP, Sun D, Oleynek JJ, et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.". Biochem. Biophys. Res. Commun. 244 (3): 832–7. doi:10.1006/bbrc.1998.8349. PMID 9535752.
Jiménez N, Calvo A, Martínez A, et al. (1999). "Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate.". J. Histochem. Cytochem. 47 (9): 1167–78. PMID 10449538.
Kuwasako K, Kitamura K, Ito K, et al. (2002). "The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors.". J. Biol. Chem. 276 (52): 49459–65. doi:10.1074/jbc.M108369200. PMID 11591721.
Forneris M, Gottardo L, Albertin G, et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.". Int. J. Mol. Med. 8 (6): 675–9. PMID 11712085.
Hänze J, Groneberg DA, Rose F, et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.". Biochem. Biophys. Res. Commun. 291 (5): 1160–5. doi:10.1006/bbrc.2002.6595. PMID 11883938.
Dumont CE, Muff R, Flühmann B, et al. (2003). "Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.". Brain Res. 955 (1-2): 64–71. PMID 12419522.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chosa E, Hamada H, Kitamura K, et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.". Biochem. Biophys. Res. Commun. 303 (1): 379–86. PMID 12646214.
Xu P, Dai AG, Zhou HD, et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]". Zhonghua Jie He He Hu Xi Za Zhi 26 (12): 765–8. PMID 14720432.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened