Adenosine A2b receptor

From Wikipedia, the free encyclopedia

The correct title of this article is Adenosine A_2b receptor. It appears incorrectly here because of technical restrictions.

Identifiers

Symbol(s)

ADORA2B; ADORA2

External IDs

OMIM: 600446 MGI: 99403 HomoloGene: 20167

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • A2B adenosine receptor activity, G-protein coupled • receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• activation of MAPK activity • cellular defense response • signal transduction • G-protein coupled receptor protein signaling pathway • adenylate cyclase activation • JNK cascade • excretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_000676 (mRNA)
NP_000667 (protein)

XM_906642 (mRNA)
XP_911735 (protein)

Location

Chr 17: 15.79 - 15.82 Mb

n/a

Pubmed search

[1]

[2]

The adenosine A_2b receptor, also known as ADORA2B, is an adenosine receptor, and also denotes the human gene incoding it.^[1]

1 Mechanism
2 Gene
3 References
4 Further reading

Mechanism

This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

Gene

The gene is located near the Smith-Magenis syndrome region on chromosome 17.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADORA2B adenosine A2b receptor.

[edit] Further reading

Stiles GL (1992). "Adenosine receptors.". J. Biol. Chem. 267 (10): 6451–4. PMID 1551861.
Pierce KD, Furlong TJ, Selbie LA, Shine J (1992). "Molecular cloning and expression of an adenosine A2b receptor from human brain.". Biochem. Biophys. Res. Commun. 187 (1): 86–93. PMID 1325798.
Jacobson MA, Johnson RG, Luneau CJ, Salvatore CA (1995). "Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene.". Genomics 27 (2): 374–6. doi:10.1006/geno.1995.1061. PMID 7558011.
Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR (1995). "Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids.". Genomics 25 (2): 605–7. PMID 7790006.
Strohmeier GR, Reppert SM, Lencer WI, Madara JL (1995). "The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.". J. Biol. Chem. 270 (5): 2387–94. PMID 7836474.
Feoktistov I, Murray JJ, Biaggioni I (1994). "Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells.". Mol. Pharmacol. 45 (6): 1160–7. PMID 8022409.
Mirabet M, Herrera C, Cordero OJ, et al. (1999). "Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation.". J. Cell. Sci. 112 ( Pt 4): 491–502. PMID 9914161.
Feoktistov I, Goldstein AE, Biaggioni I (1999). "Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells.". Mol. Pharmacol. 55 (4): 726–34. PMID 10101031.
Corset V, Nguyen-Ba-Charvet KT, Forcet C, et al. (2000). "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor.". Nature 407 (6805): 747–50. doi:10.1038/35037600. PMID 11048721.
Herrera C, Casadó V, Ciruela F, et al. (2001). "Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells.". Mol. Pharmacol. 59 (1): 127–34. PMID 11125033.
Christofi FL, Zhang H, Yu JG, et al. (2001). "Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system.". J. Comp. Neurol. 439 (1): 46–64. doi:10.1002/cne.1334. PMID 11579381.
Hayallah AM, Sandoval-Ramírez J, Reith U, et al. (2002). "1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.". J. Med. Chem. 45 (7): 1500–10. PMID 11906291.
Sitaraman SV, Wang L, Wong M, et al. (2002). "The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.". J. Biol. Chem. 277 (36): 33188–95. doi:10.1074/jbc.M202522200. PMID 12080047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I (2003). "Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.". Circ. Res. 92 (5): 485–92. doi:10.1161/01.RES.0000061572.10929.2D. PMID 12600879.
Eltzschig HK, Ibla JC, Furuta GT, et al. (2003). "Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.". J. Exp. Med. 198 (5): 783–96. doi:10.1084/jem.20030891. PMID 12939345.
Ryzhov S, Goldstein AE, Matafonov A, et al. (2004). "Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.". J. Immunol. 172 (12): 7726–33. PMID 15187156.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kolachala V, Asamoah V, Wang L, et al. (2005). "Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase.". J. Biol. Chem. 280 (6): 4048–57. doi:10.1074/jbc.M409577200. PMID 15550390.

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened