Kava

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Kava
Young Piper methysticum
Scientific classification
Kingdom: Plantae Division: Magnoliophyta Class: Magnoliopsida Order: Piperales Family: Piperaceae Genus: Piper Species: P. methysticum
Binomial name
Piper methysticum G.Forst.

Kava (Piper methysticum) (Piper Latin for "pepper", methysticum Greek for "intoxicating") is an ancient crop of the western Pacific. Other names for kava include ʻawa (Hawaii), 'ava (Samoa), yaqona (Fiji), and sakau (Pohnpei). The word kava is used to refer both to the plant and the beverage produced from its roots. Kava is a legal intoxicant in many countries and if consumed before driving would be widely regarded as DUI. It is a tranquilizer primarily consumed to relax without disrupting mental clarity. Its active ingredients are called kavalactones. In some parts of the Western World, kava extract is marketed as herbal medicine against stress, insomnia, and anxiety.

Contents 1 Preparation and consumption 1.1 Traditional preparation 1.2 Modern preparation 1.3 Pills 2 Pharmacology 2.1 Pharmacodynamics 3 Effects 4 Kava culture 5 Botany and agronomy 6 Strains and origins 7 Composition 8 Basic research on anti-cancer potential 9 Side effects and safety 9.1 Skin rashes 9.2 Liver damage incidents and regulation 9.3 Toxicology of pill form kava extracts with stems and leaves 9.4 Toxicity of traditional kava beverage preparations 9.5 Allergy 9.6 Outlook 10 See also 11 References 12 Literature 13 External links

[edit] Preparation and consumption

[edit] Traditional preparation

Kava is consumed in various ways throughout the Pacific Ocean cultures of Polynesia, Vanuatu, Melanesia and some parts of Micronesia and Australia. Traditionally it is prepared by either chewing, grinding or pounding the roots of the kava plant. Chewing is followed by depositing into a bowl, mixing with water and straining through the cloth-like fiber of a coconut tree. Grinding is done by hand against a cone-shaped block of dead coral; the hand forms a mortar and the coral a pestle. The ground root/bark is combined with only a little water, as the fresh root releases moisture during grinding. Pounding is done in a large stone with a small log. The product is then added to cold water and consumed as quickly as possible.

The extract is an emulsion of kavalactone droplets in starch. The taste is slightly pungent, while the distinctive aroma depends on whether it was prepared from dry or fresh plant, and on the variety. The colour is grey to tan to opaque greenish.

Kava prepared as described above is much more potent than processed kava. Chewing produces the strongest effect because it produces the finest particles. Fresh, undried kava produces a stronger beverage than dry kava. The strength also depends on the species and techniques of cultivation. Many find mixing powdered kava with hot water makes the drink stronger.

In Vanuatu, a strong kava drink is normally followed by a hot meal or tea. The meal traditionally follows some time after the drink so that the psychoactives are absorbed into the bloodstream quicker. Traditionally no flavoring is added.

Fijians commonly share a drink called "grog", made by pounding sun-dried kava root into a fine powder and mixing it with cold water. Traditionally, grog is drunk from the shorn half-shell of a coconut, called a "bilo." Despite tasting very much like dirty water, grog is very popular in Fiji, especially among young men, and often brings people together for storytelling and socializing.^[1]

[edit] Modern preparation

In modernized countries Kava beverage is usually made from Kava root powder. The root is dried and then finely ground into powder before being exported. Generally one tablespoon of powder is added per cup of water, but sometimes as much as a half a cup of powder (eight tablespoons) is added per cup of water to increase potency. The powder is then soaked in water for approximately 30 minutes to allow the water to completely soak through the powdered fibers. Lecithin is often added to aid in the process of emulsifying the kavalactones with water. The Kava powder, water, and lecithin are blended in a blender for several minutes then strained into a straining cloth. Nylon, cheesecloth, and silk screen are common materials for straining. Then, with the powdered pulp enclosed within the straining material, the pulp is usually massaged for five to ten minutes within the beverage by soaking it then wringing the liquid out, then soaking again and repeating. The more pressure that is applied to the wet powdered pulp while wringing it out, the more kavalactones will be released from it^{[citation needed]}. Finally the pulp resin is discarded and the beverage is enjoyed. Often coconut water, coconut milk, lemongrass, cocoa, sugar, or soy milk is added to improve flavor.

[edit] Pills

Pharmaceutical companies and herbal supplement companies extract kavalactones from the kava plant using solvents such as acetone and ethanol and produce pills standardized with between 30% and 90% kavalactones. Some kava herbal supplements have been accused of contributing to very rare but severe hepatotoxic reactions (see section on safety) such may have been due to the use of plant parts other than the root, such as stems or peelings that are known to have been exported to European manufacturers. A kava pill usually has anywhere from 75 mg to 150 mg of kavalactones. By comparison the typical bowl of traditionally prepared kava beverage has around 250 mg of kavalactones.

[edit] Pharmacology

Kava's active principal ingredients are the kavalactones, of which at least 15 have been identified and are all considered psychoactive. Only six of them produce noticeable effects, and their concentrations in kava plants vary. Different ratios can produce different effects. Kava has some abuse potential and some experts recommend cycling use over 1 to 3 months.^[2]

[edit] Pharmacodynamics

Desmethoxyyangonin, one of the six major kavalactones, is a reversible MAO-B inhibitor (Ki 280 nM)^[3] and is able to increase dopamine levels in the nucleus accumbens. This finding might correspond to the slightly euphoric action of kava.^[4]

Kavain in both enantiomeric forms inhibit the reuptake of noradrenalin at the transporter (NAT), but not of serotonin (SERT).^[5] An elevated extracellular NA level in the brain may account for the reported enhancement of attention and focus.

[edit] Effects

A moderately potent kava drink causes effects within 20–30 minutes that last for about two and a half hours, but can be felt for up to eight hours. Because of this, it is recommended to space out servings about fifteen minutes apart. Some report longer term effects up to two days after ingestion, including mental clarity, patience, and an ease of acceptance. The effects of kava are most often compared to alcohol, or a large dose of Valium.[1]

The sensations, in order of appearance, are slight tongue and lip numbing (the lips and skin surrounding may appear unusually pale); mildly talkative and sociable behavior; clear thinking; anxiolytic (calming) effects; relaxed muscles; and a very euphoric sense of well-being. The numbing of the mouth is caused by the two kavalactones kavain and dihydrokavain which cause the contraction of the blood vessels in these areas acting as a local topical anesthetic. These anesthetics can also make one's stomach feel numb. Sometimes this feeling has been mistaken for nausea. Some report that caffeine, consumed in moderation in conjunction with kava can significantly increase mental alertness.

A potent drink results in a faster onset with a lack of stimulation, the user's eyes become sensitive to light, they soon become somnolent and then have deep, dreamless sleep within 30 minutes. Sleep is often restful and there are pronounced periods of sleepiness correlating to the amount and potency of kava consumed. Unlike alcohol-induced sleep, after wakening the drinker does not experience any mental or physical after effects. However, this sleep has been reported as extremely restful and the user often wakes up more stimulated than he or she normally would. Although excessive consumption of exceptionally potent brew has been known to cause pronounced sleepiness into the next day. Although heavy doses can cause deep dreamless sleep, it is reported that many people experience lighter sleep and rather vivid dreams after drinking moderate amounts of kava. [2]

Since kavalactones are oil based, the more often kava is drunk the more it builds up in a person's system and the more potent the euphoric effects become. The first time kava is consumed, the effects are often only felt minimally. After three or four kava drinking sessions the effects should start to be felt. Most people drink between two and four (sometimes as many as six) coconut shells of kava at a time to feel the effects. Since Kava is a known detoxifier, the effects when mixed with alcohol are not desirable.

After thousands of years of use by the Polynesians and decades of research in Europe and the U.S., the traditional use of kava root has never been found to have any addictive or permanent adverse effects. Users do not develop a tolerance. While small doses of kava have been shown to slightly improve memory and cognition, large amounts at one time have been shown to cause intoxication. In Utah, California, and Hawaii there have been cases where people were charged with driving under the influence of alcohol after drinking a significant amount of kava (eight cups or more) although some of them were acquitted due to the laws not being broad enough to cover kava consumption.

[edit] Kava culture

Main article: Kava culture

Kava is used for medicinal, religious, political, cultural and social purposes throughout the Pacific. These cultures have a great respect for the plant and place a high importance on it. It is used primarily at social gatherings to increase amiability and to relax after work. It has great religious significance, being used to obtain inspiration. Among some fundamentalist Christian sects in the Western Pacific, the drink has been demonized and seen as a vice, and young members of these religions often reject its traditional use. However, among most mainline Christians denominations, i.e. the Roman Catholic, Methodist, and Anglican churches, kava drinking is encouraged as it replaces the greater danger of alcohol.

[edit] Botany and agronomy

There are several cultivars of kava, with varying concentrations of primary and secondary psychoactive substances. The largest number are grown in the Republic of Vanuatu, and so it is recognised as the "home" of kava. Kava was historically grown only in the Pacific islands of Hawaii, Federated States of Micronesia, Vanuatu, Fiji, the Samoas and Tonga. Some is grown in the Solomon Islands since World War II, but most is imported. Kava is a cash crop in Vanuatu and Fiji.

The kava shrub thrives in loose, well-drained soils where plenty of air reaches the roots. It grows naturally where rainfall is plentiful (over 2,000 mm/yr). Ideal growing conditions are 20 to 35 degrees Celsius (70 to 95 °F), and 70–100% relative humidity. Too much sunlight is harmful, especially in early growth, so kava is an understory crop.

Kava cannot reproduce sexually. Female flowers are especially rare and do not produce fruit even when hand-pollinated. Its propagation is entirely due to human efforts by the method of striking.

Traditionally, plants are harvested around 4 years of age, as older plants have higher concentrations of kavalactones. But in the past two decades farmers have been harvesting younger and younger plants, as young as 18 months. After reaching about 2 m height, plants grow a wider stalk and additional stalks, but not much taller. The roots can reach 60 cm depth.

[edit] Strains and origins

One of the most potent strains is called "Isa" in Papua New Guinea, and also called "Tuday" in Hawaii. In Vanuatu it is considered a type of "Tudei" kava, pronounced as "two-day" because it is said to have effects lasting two days due to its chemical profile being high in the kavalactone dihydromethysticin. The plant itself is a strong, very hardy, fast-growing variety with multiple light to dark green stems covered with raised dark spots.

In Vanautu there are strict laws over the exportation of Kava. Only strains they deem as "noble" varieties that are not too weak or too potent are allowed to be exported. Only the most desirable strains for every day drinking are selected to be noble varieties in order to maintain quality control. In addition their laws mandate that exported kava must be at least five years old and farmed organically. Their most popular noble strains are "Borogu" from Pentecost Island. "Melomelo" from Ambae island, (called 'sese' in North Pentecost) and "Palarasul" kava from Santo Island. In Vanuatu, Tudei (two-days) kava is reserved for special ceremonial occasions and exporting it is not allowed. "Palisi" is a popular Tudei variety.

In Hawaii there are many other strains of kava. Some of the most popular strains are the "Mahakea," "Mo'i," and "Nene" varieties. The Ali'i(kings) of old Hawaii coveted special kava they called Mo'i that had a strong cerebral effect due to a predominant amount of the kavalactone kavain. This sacred variety was so important to them, that no one but royalty could ever experience it unless suffer an untimely death.

Other strains are found in Fiji, Tonga, and Samoa.

[edit] Composition

Fresh kava root contains on average 80% water. Dried root contains approximately 43% starch, 20% fibers, 15% kavalactones, 12% water, 3.2% sugars, 3.6% proteins, and 3.2% minerals. Kavalactone content is greatest in the roots and decreases higher up the plant. Relative concentrations of 15%, 10% and 5% have been observed in the root, stump, and basal stems, respectively.

The mature roots of the kava plant are harvested after a minimum of 4 years (at least five years ideally) for peak kavalactone content. Most kava plants produce around 50 kgs (110 lbs) of root when they are harvested. Kava root is classified into two categories: crown root (or chips) and lateral root. Crown roots are the large diameter pieces that look like big (1.5 inch to 5 inches diameter) wooden poker chips. Most kava plants consist of approximately 80% crown root upon harvesting. Lateral roots are smaller diameter roots that look more like a typical root. A mature kava plant is approximately 20% lateral roots. Kava lateral roots have the highest content of kavalactones in the kava plant. "Waka" grade kava is kava that is made of lateral roots only.

[edit] Basic research on anti-cancer potential

On 15 February 2006, the Fiji Times and Fiji Live reported that researchers at the University of Aberdeen in Scotland and the Laboratoire de Biologie Moleculaire du Cancer in Luxembourg had discovered that kava may treat ovarian cancer and leukemia. Kava compounds inhibited the activation of a nuclear factor that led to the growth of cancer cells. The Aberdeen University researchers published in the journal The South Pacific Journal of Natural Science that kava methanol extracts had been shown to kill leukemia and ovarian cancer cells in test tubes.^[6] The kava compounds were shown to target only cancerous cells; no healthy cells were harmed. This may help explain why kava consumption is correlated with decreased incidence of cancer. ^[7]

Fiji Kava Council Chairman Ratu Josateki Nawalowalo welcomed the findings, saying that they would boost the kava industry. For his part, Agriculture Minister Ilaitia Tuisese called on the researchers to help persuade members of European Union to lift their ban on kava imports.

[edit] Side effects and safety

[edit] Skin rashes

Chronic and heavy use of kava for a period of three months or more has occasionally been reported to cause a scaly, yellow skin rash and eye irritation that disappears after discontinuation of the herb. The rash resembles one brought on by a niacin (Vitamin B3) deficiency; however, a double-blind, placebo-controlled study showed no change in the rash after niacin supplementation. The 29 Tonga islanders who presented with the rash after heavy kava consumption--more than 900 g/week--were given either 100 mg of oral niacinamide or placebo. No statistically significant improvement was seen in the supplementing group, suggesting niacin deficiency may not cause the rash, which is more characteristic of an acquired ichthyosis. Until more is known, however, people taking kava regularly may also wish to take a multivitamin with at least 50 to 100 mg of niacin daily.

[edit] Liver damage incidents and regulation

In 2001 concerns were raised about the safety of commercial kava products. ^[8] There have been allegations of severe liver toxicity, including liver failure in some people who had used dietary supplements containing kava extract (but not in anyone who had drunk kava the traditional way). Out of the 50 people worldwide taking kava pills and extracts that have had some type of problem, almost all of them had been mixing them with alcohol and pills that could have effects on the liver.^[8] The fact that different kava strains have slightly different chemical composition made testing for toxicity difficult as well.

The possibility of liver damage consequently prompted action of many regulatory agencies in European countries where the legal precautionary principle so mandated. In the UK, the Medicines for Human Use (Kava-kava) (Prohibition) Order 2002 prohibits the sale, supply or import of most derivative medicinal products. Kava is banned in Switzerland, France and The Netherlands^[9]. The health agency of Canada issued a stop-sale order for kava in 2002. But legislation in 2004 made the legal status of kava uncertain. The United States CDC has released a report^[10] expressing reservations about the use of kava and its possibly adverse side effects (specifically severe liver toxicity), as has the Food and Drug Administration (FDA).^[11] The Australian Therapeutic Goods Administration has recommended that no more than 250 mg of kavalactones be taken in a 24 hour period.^[12] According to the Medicines Control Agency in the U.K., there is no safe dose of kava, as there is no way to predict which individuals would have adverse reactions.^[13]

[edit] Toxicology of pill form kava extracts with stems and leaves

The legal intervention of several countries stimulated research, and hepatotoxic substances were found in the stems and leaves of the plant. Researchers from the University of Hawaii at Manoa found that an alkaloid called pipermethystine (formula 1), contained in stem peelings and leaves but not in the roots, had toxic effects on liver cells in vitro^[14] and in vivo.^[15] In rats fed with 10 mg/kg pipermethystine for two weeks, indications of hepatic toxicity were found. Comparable signs of toxicity were not detected with kava rhizome extracts (100 mg/kg, 2 weeks)^[15], (73 mg/kg, 3 months).^[16]

Flavokavain B, found in the plant's rhizome (large horizontal underground stem), may also contribute to toxic effects.^[17] And, it is known that some of the kavapyrones block several subtypes of the enzyme cytochrome P450^[18], which can result in adverse interactions with other drugs used concomitantly.

Hawaiian researchers learned from a trader in Fijian kava that European pharmaceutical companies eagerly bought up the stem and leaves peelings when demand for kava extract soared in Europe in 2000 and 2001. Before 2002, substantial amounts of aerial parts of the kava plant were being exported to North America and Europe and obviously used for the production of commercial pill extracts. For traditional use in the South Pacific, stem peelings and leaves are discarded, and only the rhizomes are used and extracted with water. This may explain why native populations that make heavy use of kava experience side effects that are mild, temporary, and confined to the skin, whereas industrialized countries that have newly adopted kava occasionally show severe, acute responses.

A medical conference in Fiji determined that the high concentrations of kava resins in pill form extracts alone could have been the culprit for the liver damage incidents.

[edit] Toxicity of traditional kava beverage preparations

Kava has been consumed heavily as a beverage in the south Pacific for around 3000 years with no reports of liver problems. One study has reported that when kava preparations are made with the root of the plant no toxicity is found.^[19] However, in one study some changes in liver function are noticed. The effects are temporary and reversible when discontinuing kava use.^[20] Although kava root does not cause liver toxicity, there is evidence of health concerns among heavy drinkers, including poor nutrition and a rise in liver enzymes.^[21]

The plant also contains glutathione. In extracts its concentration varies depending on the lipophilicity of the applied solvent; the amount is higher in aqueous extracts. Glutathione in kava beverage preparations is able to provide a certain protection of liver cells.^[22] However, kava extracts in pill form will not have the glutathione in it to help protect the liver.

[edit] Allergy

Literature suggests that <0.5% of people that take kava have an allergic reaction to it.^{[citation needed]} Allergic reactions are usually mild and include itchy skin or itchy throat, and hives on the skin usually prevalent on the user's belly region. If someone has an allergy to any relative of the pepper family, such as black pepper, they have a higher chance of having a kava allergy.^{[citation needed]}

[edit] Outlook

The issue has long been controversial and the debate fuelled by conflicting economic interests of monopoly-driven pharmaceutical companies, concerned with competition in anti-anxiety drug sales, and kava-exporting nations of the Pacific Islands as well as disagreements between the medical establishment and proponents of herbal and natural medicine. The German Federal Institute for Drugs and Medical Devices (BfArM), which in 2002 temporarily inactivated kava registrations, asked the producers to provide new clinical data by June 2007, in which case a reinstitution of the kava products on the market might again be possible.^[23]

A New Zealand committee from the New Zealand Association of Medical Herbalists that considered the issue commented in its summary: "A comparison with paracetamol-associated hepatotoxicity, results in the conclusion that these potential risks for kava are dramatically less than that of a popular non prescription drug widely sold through grocery outlets."^[24][25] The NZ government is currently only considering requiring a suitable warning label standard to go on kava products.

[edit] See also

• Alcohol and Drugs History Society

[edit] References

[edit] Literature

• Lebot, Vincent et al. "Kava: The Pacific Drug", New Haven: Yale University Press, 1992. ISBN 0-300-05213-8

• The Mars Trilogy by Kim Stanley Robinson, Spectra, 1993. ISBN 0-553-09204-9. Contains many references to Kava, and "Kavajava" - kava mixed with coffee. The book uses kava as the social drink of choice for the "Martians" (human colonizers of Mars).

[edit] External links

The external links in this article may not follow Wikipedia's content policies or guidelines. Please improve this article by removing excessive or inappropriate external links.

• Farmers Bookshelf - Information on Tropical Crop Production in Hawaiʻi (Site has javascript navigation and kava (ʻawa) pages cannot be directly linked: click on "nutraceuticals", then "'Awa".)
• The Kava culture in Vanuatu
• Kava Ban documents
• Erowid's Kava vault
• How to prepare Kava (Erowid)
• Lycaeum: Includes list of isolated chemicals
• Kava news page
• Hawaiʻi Pacific Islands Kava Festival - An education, cultural event held more in Hawaii sponsored by the nonprofit, ʻAwa Development Council
• European Kava Forum

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