蛋白酶抑制剂
维基百科,自由的百科全书
蛋白酶抑制剂是带有环状结构的肽化合物,可竞争性或非竞争性抑制蛋白酶活性,此外,蛋白酶抑制剂还可以降低白介素-1β转换酶的表达,从而减少CD4细胞凋亡,FDA已批准上市7种药物(SQV、RTV、IDV、NFV、APV等)。 When HIV infects a cell in a person's body, it copies it's own genetic code into the cell's DNA. In this way, the cell is then "programmed" to create new copies of HIV. Once HIV's genetic material (RNA) is inside a T-cell's DNA, the cell produces a long strand of genetic material that must be cut up and put together correctly to form new copies of the virus. Cutting up this strand requires a scissor-like enzyme called protease. PIs block this enzyme and prevent the cell from producing new viruses.