Varicellovirus
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Varicellovirus (var′i-sel′ō-vi′rŭs) is a genus of Alphaherpesvirinae.
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[edit] Morphology
Varicellovirus is the causative agent of chickenpox in humans. While the infection is usually self-limiting, virions remain in a latent state in the dorsal root ganglia. The virus can be reactivated later in life, causing herpes zoster. Virions consist of an envelope, a tegument, a nucleocapsid, and a core. The viral capsid is contained within a spherical envelope which is 120-200 nm in diameter. Surface projections on envelope (viral receptors) are densely dispersed and contain small spikes that evenly dot the surface.
Tegument is disordered; they do not display a structure and proteins in variable amounts are arranged sometimes in an asymmetric layer located between envelope and capsid.
Capsid/nucleocapsid is round and exhibits icosahedral symmetry. The capsid is isometric and has a diameter of 100-110 nm. The capsid consists of 162 capsomer proteins with a hexagonal base and a hole running half-way down the long axis. The core consists of a fibrillar spool on which the DNA is wrapped. The end of the fibers are anchored to the underside of the capsid shell [1].
[edit] Hosts
The virus's natural host is a single type of vertebrate host. It is also able to infect Homo sapiens (humans) [2].
[edit] Literature
- ^ ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/
- ^ Davison, A.J. (2002). Evolution of the herpesviruses. Vet. Microbial., 86, 69-88.
[edit] See also
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