UQCRFS1

From Wikipedia, the free encyclopedia

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

PDB rendering based on 1be3.

Available structures: 1be3, 1bgy, 1l0l, 1l0n, 1ntk, 1ntm, 1ntz, 1nu1, 1pp9, 1ppj, 1qcr, 1rie, 1sqb, 1sqp, 1sqq, 1sqv, 1sqx, 2a06, 2fyu

Identifiers

Symbol(s)

UQCRFS1; RIS1

External IDs

OMIM: 191327 MGI: 1913944 HomoloGene: 4378

Gene ontology
Molecular Function:	• iron ion binding • ubiquinol-cytochrome-c reductase activity • oxidoreductase activity • metal ion binding • 2 iron, 2 sulfur cluster binding
Cellular Component:	• mitochondrion • mitochondrial respiratory chain complex III • membrane • integral to membrane
Biological Process:	• electron transport • transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006003 (mRNA)
NP_005994 (protein)

NM_025710 (mRNA)
NP_079986 (protein)

Location

Chr 19: 34.39 - 34.4 Mb

Chr 13: 30.55 - 30.55 Mb

Pubmed search

[1]

[2]

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, is a human gene.^[1]

[edit] References

^ Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1.

[edit] Further reading

Nishikimi M, Hosokawa Y, Toda H, et al. (1990). "The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis.". Biochem. Int. 20 (1): 155-60. PMID 2158323.
Shimomura Y, Nishikimi M, Ozawa T (1986). "Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1.". J. Biol. Chem. 260 (28): 15075-80. PMID 2999105.
Pennacchio LA, Bergmann A, Fukushima A, et al. (1995). "Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein.". Gene 155 (2): 207-11. PMID 7721092.
Duncan AM, Anderson L, Duff C, et al. (1994). "Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome.". Genomics 21 (1): 281-3. doi:10.1006/geno.1994.1260. PMID 8088805.
Sarto C, Marocchi A, Sanchez JC, et al. (1997). "Renal cell carcinoma and normal kidney protein expression.". Electrophoresis 18 (3-4): 599-604. doi:10.1002/elps.1150180343. PMID 9150947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kaneko SJ, Gerasimova T, Smith ST, et al. (2003). "CA125 and UQCRFS1 FISH studies of ovarian carcinoma.". Gynecol. Oncol. 90 (1): 29-36. PMID 12821338.
Ohashi Y, Kaneko SJ, Cupples TE, Young SR (2004). "Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples.". Gynecol. Oncol. 93 (1): 54-8. doi:10.1016/j.ygyno.2004.01.019. PMID 15047214.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.