U4atac minor spliceosomal RNA
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U4atac minor spliceosomal RNA is a ncRNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type) [1].
U4atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U6atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing [2]. U4atac also contains an 3' Sm protein binding site which has been shown to be essential for splicing activity [2] . U4atac is the functional analog of U4 spliceosomal RNA in the major U2-type spliceosomal complex [2] .
The Drosophila U4atac snRNA has an additional predicted 3' stem loop terminal to the Sm binding site [3].
[edit] References
- ^ Lorkovic ZJ, Lehner R, Forstner C, Barta A; (2005). "Evolutionary conservation of minor U12-type spliceosome betweenplants and humans.". RNA 11: 1095–1107. doi:. PMID 15987817.
- ^ a b c Shukla GC, Cole AJ, Dietrich RC, Padgett RA; (2002). "Domains of human U4atac snRNA required for U12-dependent splicing invivo.". Nucleic Acids Res 30: 4650–4657. doi:. PMID 12409455.
- ^ Padgett RA, Shukla GC; (2002). "A revised model for U4atac/U6atac snRNA base pairing.". RNA 8: 125–128. doi:. PMID 11911359.
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