Sulfamethizole


Sulfamethizole
Systematic (IUPAC) name
4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)- benzenesulfonamide
Identifiers
CAS number	144-82-1
ATC code	B05CA04 D06 BA04, J01 EB02, S01 AB01
PubChem	5328
DrugBank	APRD00684
Chemical data
Formula	C₉H₁₀N₄O₂S₂
Mol. mass	270.333 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	98–99%
Metabolism	?
Half life	3–8 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Sulfamethizole is a sulfonamide antibiotic.

[edit] External links

Ratanajamit C, Skriver M, Nørgaard M, Jepsen P, Schønheyder H, Sørensen H (2003). "Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study.". J Antimicrob Chemother 52 (5): 837–41. doi:10.1093/jac/dkg438. PMID 14519675.
Kerrn M, Frimodt-Møller N, Espersen F (2003). "Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model.". Antimicrob Agents Chemother 47 (3): 1002–9. doi:10.1128/AAC.47.3.1002-1009.2003. PMID 12604534.
Watanabe H, Hastings J (1990). "Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine.". Biochim Biophys Acta 1017 (3): 229–34. doi:10.1016/0005-2728(90)90189-B. PMID 2372557.

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v • d • e Antibiotics and chemotherapeutics for dermatological use (D06)

Antibiotics: tetracycline and derivatives	Demeclocycline - Chlortetracycline - Oxytetracycline - Tetracycline

Antibiotics: other	Fusidic acid - Chloramphenicol - Neomycin - Bacitracin - Gentamicin - Tyrothricin - Mupirocin - Nadifloxacin - Virginiamycin - Rifaximin - Amikacin

Chemotherapeutics: sulfonamides	Silver sulfadiazine - Sulfathiazole - Mafenide - Sulfamethizole - Sulfanilamide - Sulfamerazine

Chemotherapeutics: antivirals	Idoxuridine - Tromantadine - Aciclovir - Podophyllotoxin - Inosine - Penciclovir - Lysozyme - Ibacitabine - Edoxudine - Imiquimod - Docosanol

Chemotherapeutics: other	Metronidazole

v • d • e Antibacterials for systemic use: sulfonamides (sulfa drugs) and trimethoprim (J01E)

Trimethoprim and derivatives	Trimethoprim • Brodimoprim

Short-acting sulfonamides	Sulfaisodimidine • Sulfamethizole • Sulfadimidine • Sulfapyridine • Sulfafurazole • Sulfanilamide • Sulfathiazole • Sulfathiourea

Intermediate-acting sulfonamides	Sulfamethoxazole • Sulfadiazine • Sulfamoxole

Long-acting sulfonamides	Sulfadimethoxine • Sulfalene • Sulfametomidine • Sulfametoxydiazine • Sulfamethoxypyridazine • Sulfaperin • Sulfamerazine • Sulfaphenazole • Sulfamazon

Combinations	Sulfamethoxazole and trimethoprim

Other	Mafenide • Prontosil • Sulfacetamide • Sulfasalazine • Sulfisoxazole