Sphinganine-1-phosphate aldolase

From Wikipedia, the free encyclopedia

In enzymology, a sphinganine-1-phosphate aldolase (EC 4.1.2.27) is an enzyme that catalyzes the chemical reaction

sphinganine 1-phosphate phosphoethanolamine + palmitaldehyde

Hence, this enzyme has one substrate, sphinganine 1-phosphate, and two products, phosphoethanolamine and palmitaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming). Other names in common use include dihydrosphingosine 1-phosphate aldolase, sphinganine-1-phosphate alkanal-lyase, sphinganine-1-phosphate lyase, and sphinganine-1-phosphate palmitaldehyde-lyase. This enzyme participates in sphingolipid metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.1.2.27
• BRENDA references for 4.1.2.27 (Recommended.)
• PubMed references for 4.1.2.27
• PubMed Central references for 4.1.2.27
• Google Scholar references for 4.1.2.27
• Stoffel W, LeKim D, Sticht G (1969). "Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase)". Hoppe. Seylers. Z. Physiol. Chem. 350: 1233–41. PMID 5389296. 

[edit] External links

The CAS registry number for this enzyme class is 39391-27-0.

• IUBMB entry for 4.1.2.27

• KEGG entry for 4.1.2.27

• BRENDA entry for 4.1.2.27

• NiceZyme view of 4.1.2.27

• EC2PDB: PDB structures for 4.1.2.27

• PRIAM entry for 4.1.2.27

• PUMA2 entry for 4.1.2.27

• IntEnz: Integrated Enzyme entry for 4.1.2.27

• MetaCyc entry for 4.1.2.27

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008117: sphinganine-1-phosphate aldolase

• AMIGO entry for GO code 0008117: sphinganine-1-phosphate aldolase