Sonic spray ionization
From Wikipedia, the free encyclopedia
Sonic spray ionization (SSI) is method for creating ions from a liquid solution, for example, a mixture of methanol and water. A pneumatic nebulizer is used to turn the solution into a supersonic spray of small droplets. Ions are formed when the solvent evaporates and the statistically unbalanced charge distribution on the droplets leads to a net charge. Complete desolvation results in ions that can be detected using mass spectrometry.[1]
[edit] Applications
Sonic spray ionization has been coupled with high performance liquid chromatography for the analysis of drugs.[2][3] Oligonucleotides have been studied with this method.[4][5] SSI has been used in a manner similar to desorption electrospray ionization[6] and has been couplet with thin layer chromatography in this manner.[7]
[edit] See also
[edit] References
- ^ Hirabayashi A, Sakairi M, Koizumi H (1995). "Sonic spray mass spectrometry". Anal. Chem. 67 (17): 2878-82. PMID 8779414.
- ^ Arinobu T, Hattori H, Seno H, Ishii A, Suzuki O (2002). "Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites". J. Am. Soc. Mass Spectrom. 13 (3): 204-8. PMID 11908800.
- ^ Dams R, Benijts T, Günther W, Lambert W, De Leenheer A (2002). "Sonic spray ionization technology: performance study and application to a LC/MS analysis on a monolithic silica column for heroin impurity profiling". Anal. Chem. 74 (13): 3206-12. PMID 12141684.
- ^ Huang M, Hirabayashi A, Okumura A, Hirabayashi Y (2001). "Matrix effect on the analysis of oligonucleotides by using a mass spectrometer with a sonic spray ionization source". Anal Sci 17 (10): 1179-82. PMID 11990592.
- ^ Huang M, Hirabayashi A (2002). "Multi-charged oligonucleotide ion formation in sonic spray ionization". Anal Sci 18 (4): 385-90. PMID 11999509.
- ^ Haddad R, Sparrapan R, Eberlin MN (2006). "Desorption sonic spray ionization for (high) voltage-free ambient mass spectrometry". Rapid Commun. Mass Spectrom. 20 (19): 2901-5. doi:. PMID 16941547.
- ^ Haddad R, Milagre HM, Catharino RR, Eberlin MN (2008). "Easy Ambient Sonic-Spray Ionization Mass Spectrometry Combined with Thin-Layer Chromatography". Anal. Chem.. doi:. PMID 18331004.
