SON

From Wikipedia, the free encyclopedia

SON DNA binding protein

Identifiers

SON; BASS1; C21orf50; DBP-5; FLJ21099; FLJ33914; KIAA1019; NREBP; SON3

External IDs

OMIM: 182465 MGI: 98353 HomoloGene: 10551

Gene ontology
Molecular Function:	• DNA binding • double-stranded RNA binding • protein binding
Cellular Component:	• cellular_component • intracellular • nucleus
Biological Process:	• anti-apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032195 (mRNA)
NP_115571 (protein)

NM_019973 (mRNA)
NP_064357 (protein)

Location

Chr 21: 33.84 - 33.87 Mb

Chr 16: 91.54 - 91.57 Mb

Pubmed search

[1]

[2]

SON DNA binding protein, also known as SON, is a human gene.^[1]

The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SON SON DNA binding protein.

[edit] Further reading

Mattioni T, Hume CR, Konigorski S, et al. (1992). "A cDNA clone for a novel nuclear protein with DNA binding activity.". Chromosoma 101 (10): 618–24. PMID 1424986.
Bliskovskiĭ VV, Berdichevskiĭ FB, Tkachenko AV, et al. (1992). "[Coding part of the son gene small transcript contains four areas of complete tandem repeats]". Mol. Biol. (Mosk.) 26 (4): 793–806. PMID 1435773.
Bliskovskiĭ VV, Kirillov AV, Zakhar'ev VM, Chumankov IM (1992). "[The human son gene: the large and small transcripts contains various 5'-terminal sequences]". Mol. Biol. (Mosk.) 26 (4): 807–12. PMID 1435774.
Tassone F, Cheng S, Gardiner K (1993). "Analysis of chromosome 21 yeast artificial chromosome (YAC) clones.". Am. J. Hum. Genet. 51 (6): 1251–64. PMID 1463009.
Chumakov IM, Berdichevskiĭ FB, Sokolova NV, et al. (1991). "[Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells]". Mol. Biol. (Mosk.) 25 (3): 731–9. PMID 1944255.
Berdichevskiĭ FB, Chumakov IM, Kiselev LL (1988). "[Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins]". Mol. Biol. (Mosk.) 22 (3): 794–801. PMID 3054499.
Khan IM, Fisher RA, Johnson KJ, et al. (1994). "The SON gene encodes a conserved DNA binding protein mapping to human chromosome 21.". Ann. Hum. Genet. 58 (Pt 1): 25–34. PMID 8031013.
Cheng S, Lutfalla G, Uze G, et al. (1993). "GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16.". Mamm. Genome 4 (6): 338–42. PMID 8318737.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.
Greenhalf W, Lee J, Chaudhuri B (1999). "A selection system for human apoptosis inhibitors using yeast.". Yeast 15 (13): 1307–21. doi:10.1002/(SICI)1097-0061(19990930)15:13<1307::AID-YEA455>3.0.CO;2-3. PMID 10509013.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Wynn SL, Fisher RA, Pagel C, et al. (2001). "Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes.". Genomics 68 (1): 57–62. doi:10.1006/geno.2000.6254. PMID 10950926.
Sun CT, Lo WY, Wang IH, et al. (2001). "Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON.". J. Biol. Chem. 276 (26): 24059–67. doi:10.1074/jbc.M101330200. PMID 11306577.
Reymond A, Friedli M, Henrichsen CN, et al. (2002). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.". Genomics 78 (1-2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.
Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers.". J. Biol. Chem. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Casadei R, Strippoli P, D'Addabbo P, et al. (2004). "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs.". Gene 321: 185–93. PMID 14637006.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.