Serine C-palmitoyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a serine C-palmitoyltransferase (EC 2.3.1.50) is an enzyme that catalyzes the chemical reaction

palmitoyl-CoA + L-serine CoA + 3-dehydro-D-sphinganine + CO₂

Thus, the two substrates of this enzyme are palmitoyl-CoA and L-serine, whereas its 3 products are CoA, 3-dehydro-D-sphinganine, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating). Other names in common use include serine palmitoyltransferase, SPT, 3-oxosphinganine synthetase, and acyl-CoA:serine C-2 acyltransferase decarboxylating. This enzyme participates in sphingolipid metabolism. It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2JG2 and 2JGT.

[edit] References

• IUBMB entry for 2.3.1.50
• BRENDA references for 2.3.1.50 (Recommended.)
• PubMed references for 2.3.1.50
• PubMed Central references for 2.3.1.50
• Google Scholar references for 2.3.1.50
• Brady RN, Di Mari SJ, Snell EE (1969). "Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri". J. Biol. Chem. 244: 491–6. PMID 4388074. 
• Stoffel W, LeKim D, Sticht G (1968). "Biosynthesis of dihydrosphingosine in vitro". Hoppe. Seylers. Z. Physiol. Chem. 349: 664–70. PMID 4386961. 

[edit] External links

The CAS registry number for this enzyme class is 62213-50-7.

• IUBMB entry for 2.3.1.50

• KEGG entry for 2.3.1.50

• BRENDA entry for 2.3.1.50

• NiceZyme view of 2.3.1.50

• EC2PDB: PDB structures for 2.3.1.50

• PRIAM entry for 2.3.1.50

• PUMA2 entry for 2.3.1.50

• IntEnz: Integrated Enzyme entry for 2.3.1.50

• MetaCyc entry for 2.3.1.50

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004758: serine C-palmitoyltransferase

• AMIGO entry for GO code 0004758: serine C-palmitoyltransferase

v • d • e Transferases: acyltransferases (EC 2.3) 2.3.1: other than amino-acyl groups (mostly acetyltransferases) N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase (CPT1, CPT2) - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase (P300/CBP) - Serotonin N-acetyl transferase - Serine C-palmitoyltransferase (SPTLC1, SPTLC2) - HGSNAT 2.3.2 - Aminoacyltransferases Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII) 2.3.3 - converted into alkyl on transfer Citrate synthase - ATP citrate lyase - HMG-CoA synthase

v • d • e Metabolism: lipid metabolism - glycolipid/sphingolipid enzymes To glycosphingolipid Glycosyltransferase - Sulfotransferase To ceramide From ganglioside: Beta-galactosidase - Hexosaminidase A - Neuraminidase - Beta-galactosidase - Glucocerebrosidase From globoside: Hexosaminidase B - Alpha-galactosidase - Beta-galactosidase - Glucocerebrosidase From sphingomyelin: Sphingomyelin phosphodiesterase 1 From sulfatide: Arylsulfatase A - Galactosylceramidase To sphingosine Ceramidase Other Serine C-palmitoyltransferase (SPTLC1) see also lipid storage disorders