RS 67333
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| RS 67333 | |
|---|---|
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| IUPAC name | 1-(4-Amino-5-chloro-2-methoxyphenyl)-
3-(1-butyl-4-piperidinyl)-1-propanone |
| Identifiers | |
| CAS number | [160845-95-4] |
| SMILES | C(CCC1CCN(CC1)CCCC)(=O)c1c(cc(c(c1)Cl)N)OC |
| Properties | |
| Molecular formula | C19H29N2O2Cl |
| Molar mass | 352.9 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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RS 67333 is a 5-HT4 receptor partial agonist, being researched as a possible rapid acting antidepressant[1], nootropic[2], and treatment for Alzheimer's[3].
[edit] References
- ^ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. (2007). "Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.". Neuron. 55 (5): 712–25. doi:. PMID 17785179.
- ^ Lamirault L, Simon H. (2001). "Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.". Neuropharmacology. 41 (7): 844–53. doi:. PMID 11684148.
- ^ Cho S, Hu Y. (2007). "Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.". Experimental Neurology. 203 (1): 274–8. doi:. PMID 16978609.
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