RPS20

From Wikipedia, the free encyclopedia

Ribosomal protein S20

Identifiers

RPS20; FLJ27451; MGC102930

External IDs

OMIM: 603682 MGI: 1914677 HomoloGene: 37417

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome • protein binding
Cellular Component:	• intracellular • cytosolic small ribosomal subunit (sensu Eukaryota)
Biological Process:	• translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001023 (mRNA)
NP_001014 (protein)

NM_026147 (mRNA)
NP_080423 (protein)

Location

Chr 8: 57.15 - 57.15 Mb

Chr 4: 3.76 - 3.76 Mb

Pubmed search

[1]

[2]

Ribosomal protein S20, also known as RPS20, is a human gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPS20 ribosomal protein S20.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933-47. PMID 8722009.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243-50. PMID 7821789.
Chu W, Presky DH, Swerlick RA, Burns DK (1993). "Human ribosomal protein S20 cDNA sequence.". Nucleic Acids Res. 21 (7): 1672. PMID 8479924.
Kiss-László Z, Henry Y, Bachellerie JP, et al. (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs.". Cell 85 (7): 1077-88. PMID 8674114.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144-9. PMID 8706699.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509-23. PMID 9582194.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.". Genome Res. 12 (3): 379-90. doi:10.1101/gr.214202. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438-46. doi:10.1110/ps.041293005. PMID 15883184.
De Bortoli M, Castellino RC, Lu XY, et al. (2006). "Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.". BMC Cancer 6: 223. doi:10.1186/1471-2407-6-223. PMID 16968546.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575-88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Frum R, Busby SA, Ramamoorthy M, et al. (2007). "HDM2-binding partners: interaction with translation elongation factor EF1alpha.". J. Proteome Res. 6 (4): 1410-7. doi:10.1021/pr060584p. PMID 17373842.