Rhamnulose-1-phosphate aldolase

From Wikipedia, the free encyclopedia

In enzymology, a rhamnulose-1-phosphate aldolase (EC 4.1.2.19) is an enzyme that catalyzes the chemical reaction

L-rhamnulose 1-phosphate $\rightleftharpoons$ glycerone phosphate + (S)-lactaldehyde

Hence, this enzyme has one substrate, L-rhamnulose 1-phosphate, and two products, glycerone phosphate and (S)-lactaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-rhamnulose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include rhamnulose phosphate aldolase, L-rhamnulose 1-phosphate aldolase, L-rhamnulose-phosphate aldolase, and L-rhamnulose-1-phosphate lactaldehyde-lyase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1GT7 and 1OJR.

[edit] References

IUBMB entry for 4.1.2.19
BRENDA references for 4.1.2.19 (Recommended.)
PubMed references for 4.1.2.19
PubMed Central references for 4.1.2.19
Google Scholar references for 4.1.2.19
Chiu TH, Feingold DS (1969). "L-rhamnulose 1-phosphate aldolase from Escherichia coli Crystallization and properties". Biochemistry. 8: 98–108. doi:10.1021/bi00829a015. PMID 4975916.
Sawada H and Takagi Y (1964). "The metabolism of L-rhamnose in Escherichia coli. 3 L-Rhamulose-phosphate aldolase". Biochim. Biophys. Acta 92: 26–32.