Rab geranylgeranyltransferase

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Rab geranylgeranyltransferase, alpha subunit
Identifiers
Symbol	RABGGTA
Entrez	5875
HUGO	9795
OMIM	601905
RefSeq	NM_004581
UniProt	Q92696
Other data
Locus	Chr. 14 q11.2

Rab geranylgeranyltransferase, beta subunit
Identifiers
Symbol	RABGGTB
Entrez	5876
HUGO	9796
OMIM	179080
RefSeq	NM_004582
UniProt	P53611
Other data
Locus	Chr. 1 p31

Rab geranylgeranyltransferase, or Geranylgeranyltransferase II is one of the three prenyltransferases. It transfers (usually) two geranylgeranyl groups to the cystein(s) at the C-terminus of Rab proteins.

The C-terminus of Rab proteins varies in length and sequence and is referred to as hypervariable. Thus Rab proteins do not have a consensus sequence, such as the CAAX box, which the Rab geranylgeranyltransferase can recognise. Instead Rab proteins are bound by the Rab escort protein (REP) over a more conserved region of the Rab protein and then presented to the Rab geranylgeranyltransferase.

Once Rab proteins are prenylated the lipid anchor(s) ensure that Rabs are no longer soluble. REP therefore plays an important role in binding and solubilising the geranylgeranyl groups and delivers the Rab protein to the relevant cell membrane.

[edit] See also

• Prenylation
• Farnesyltransferase
• Geranylgeranyltransferase type 1 - also referred to as Geranylgeranyltranferase 1 or just Geranylgeranyltranferase

[edit] External links

• MeSH Rab+geranylgeranyltransferase