PYCR1

From Wikipedia, the free encyclopedia

Pyrroline-5-carboxylate reductase 1

PDB rendering based on 2ger.

Available structures: 2ger, 2gr9, 2gra, 2izz

Identifiers

Symbol(s)

PYCR1; P5C; P5CR; PIG45; PP222; PYCR

External IDs

OMIM: 179035 MGI: 2384795 HomoloGene: 56002

Gene ontology
Molecular Function:	• pyrroline-5-carboxylate reductase activity • oxidoreductase activity
Biological Process:	• electron transport • proline biosynthetic process • amino acid biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006907 (mRNA)
NP_008838 (protein)

NM_144795 (mRNA)
NP_659044 (protein)

Location

Chr 17: 77.48 - 77.49 Mb

Chr 11: 120.46 - 120.46 Mb

Pubmed search

[1]

[2]

Pyrroline-5-carboxylate reductase 1, also known as PYCR1, is a human gene.^[1]

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1.

[edit] Further reading

Herzfeld A, Legg MA, Greengard O (1978). "Human colon tumors: enzymic and histological characteristics.". Cancer 42 (3): 1280-3. PMID 212173.
Dougherty KM, Brandriss MC, Valle D (1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae.". J. Biol. Chem. 267 (2): 871-5. PMID 1730675.
Merrill MJ, Yeh GC, Phang JM (1989). "Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.". J. Biol. Chem. 264 (16): 9352-8. PMID 2722838.
Yeh GC, Roth EF, Phang JM, et al. (1984). "The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects.". J. Biol. Chem. 259 (9): 5454-8. PMID 6201483.
Herzfeld A, Greengard O (1981). "Enzyme activities in human fetal and neoplastic tissues.". Cancer 46 (9): 2047-54. PMID 6253048.
Yeh GC, Harris SC, Phang JM (1981). "Pyrroline-5-carboxylate reductase in human erythrocytes.". J. Clin. Invest. 67 (4): 1042-6. PMID 6894153.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Basch JJ, Wickham ED, Farrell HM (1997). "Pyrroline-5-carboxylate reductase in lactating bovine mammary glands.". J. Dairy Sci. 79 (8): 1361-8. PMID 8880459.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Meng Z, Lou Z, Liu Z, et al. (2006). "Crystal structure of human pyrroline-5-carboxylate reductase.". J. Mol. Biol. 359 (5): 1364-77. doi:10.1016/j.jmb.2006.04.053. PMID 16730026.

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v • d • e

Metabolism: amino acid metabolism - synthesis and catabolism enzymes (essential in CAPS)

K→acetyl-CoA

G→pyruvate

glycine→serine→	Serine hydroxymethyltransferase - Serine dehydratase

alanine→	Alanine transaminase

cysteine→	D-cysteine desulfhydrase

threonine→	L-threonine dehydrogenase

G→glutamate


HISTIDINE→	Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase

proline→	Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1

arginine→	Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase

→alpha-ketoglutarate→TCA	Glutamate dehydrogenase

G→propionyl-CoA

G→fumarate


PHENYLALANINE→tyrosine→	Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase